Mikami Yoshiki, Kiyokawa Takako, Sasajima Yuko, Teramoto Norihiro, Wakasa Tomoko, Wakasa Kenichi, Hata Sakae
Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Histopathology. 2009 Jan;54(2):184-91. doi: 10.1111/j.1365-2559.2008.03202.x.
To describe the gastric phenotype of synchronous mucinous metaplasia and neoplasms of the female genital tract (SMMN-FGT).
Six patients (mean age 57 years, range 39-83 years) were diagnosed with SMMN-FGT. All six patients had mucinous metaplasia of endometrium, which showed features of lobular endocervical glandular hyperplasia (LEGH)/pyloric gland metaplasia (PGM) in five and was associated with mucinous adenocarcinoma in three. Five patients had mucinous metaplasia of the fallopian tubes, of which three showed borderline features. Two patients had mucinous borderline tumour of the ovary. Five patients had cervical lesions including LEGH/PGM associated with either adenocarcinoma in situ or minimal deviation adenocarcinoma of the cervix. All mucinous lesions were positive for HIK1083 and/or MUC6. One patient with minimal deviation adenocarcinoma involving the vagina died of her disease, whereas five patients, including three with microinvasion and three with positive peritoneal cytology or mucinous ascites, were alive without recurrence after a mean follow-up of 46 months (range 13-102 months).
There is a close association between SMMN-FGT and LEGH/PGM. Microinvasion and positive peritoneal cytology may not have an influence on outcome.
描述女性生殖道同步性黏液化生和肿瘤（SMMN-FGT）的胃部表型。
6例患者（平均年龄57岁，范围39 - 83岁）被诊断为SMMN-FGT。所有6例患者均有子宫内膜黏液化生，其中5例表现为小叶状宫颈腺增生（LEGH）/幽门腺化生（PGM）特征，3例与黏液腺癌相关。5例患者有输卵管黏液化生，其中3例表现为交界性特征。2例患者有卵巢黏液性交界性肿瘤。5例患者有宫颈病变，包括与宫颈原位腺癌或微小偏离腺癌相关的LEGH/PGM。所有黏液性病变HIK1083和/或MUC6均呈阳性。1例累及阴道的微小偏离腺癌患者死于该疾病，而5例患者，包括3例微浸润患者和3例腹膜细胞学阳性或有黏液性腹水患者，平均随访46个月（范围为13 - 102个月）后存活且无复发。
SMMN-FGT与LEGH/PGM之间存在密切关联。微浸润和腹膜细胞学阳性可能对预后无影响。
