与大脑中动脉粥样硬化性狭窄相关的局部动脉几何特征
Local artery geometry characteristics associated with middle cerebral atherosclerotic stenosis.
作者信息
Yang Yujia, Zhang Zhao, Luo Anling, Deng Yiting, Li Xuzi, Ye Jing, He Li, Zhou Muke
机构信息
West China Hospital of Sichuan University, Chengdu, China.
出版信息
Neuroradiology. 2025 Mar;67(3):707-715. doi: 10.1007/s00234-025-03563-8. Epub 2025 Feb 19.
OBJECTIVES
The impact of artery geometry on intracranial atherosclerosis (ICAS) is unclear. To investigate the association between local artery geometry characteristics and middle cerebral atherosclerotic stenosis.
METHODS
This was a case-control study. ICAS patients with more than 50% stenosis in one M1 pre-bifurcation segment but no significant stenosis on the other side were included. The stenosis degree, diameter, length, angle, and morphology (straight-shape, U-shape, and S-shape) of the M1 pre-bifurcation segments were measured by using digital subtraction angiography (DSA) combined with computed tomography angiography (CTA) and 3D reconstruction imaging. The geometry characteristics on both sides were compared. The conditional multivariate Logistics regression was used to investigate the association between stenotic sides and the geometry characteristics.
RESULT
A total of 133 patients, 266 M1 pre-bifurcation segments, were included. Compared with non-stenotic sides, stenotic sides showed smaller diameters (2.873 ± 0.456 mm vs. 2.993 ± 0.360 mm, P = 0.002) and larger tortuosity index (7.61% vs. 6.45%, P = 0.048). The S-shape M1 pre-bifurcation segment was independently associated with the stenotic sides (OR = 3.509, 95% CI 1.176-10.468, P = 0.024). The stenotic side was worse fitted to Murray's law (mean square error 0.326 vs. 0.313).
CONCLUSIONS
The morphology of the M1 pre-bifurcation segment was associated with middle cerebral atherosclerotic stenosis.
目的
动脉几何形态对颅内动脉粥样硬化（ICAS）的影响尚不清楚。本研究旨在探讨局部动脉几何形态特征与大脑中动脉粥样硬化性狭窄之间的关联。
方法
本研究为病例对照研究。纳入一侧M1分叉前段狭窄超过50%而另一侧无明显狭窄的ICAS患者。采用数字减影血管造影（DSA）联合计算机断层血管造影（CTA）及三维重建成像测量M1分叉前段的狭窄程度、直径、长度、角度及形态（直线形、U形和S形）。比较两侧的几何形态特征。采用条件多因素Logistic回归分析狭窄侧与几何形态特征之间的关联。
结果
共纳入133例患者，266个M1分叉前段。与非狭窄侧相比，狭窄侧直径较小（2.873±0.456mm对2.993±0.360mm，P=0.002），迂曲指数较大（7.61%对6.45%，P=0.048）。S形M1分叉前段与狭窄侧独立相关（OR=3.509，95%CI 1.176-10.468，P=0.024）。狭窄侧对Murray定律的拟合度较差（均方误差0.326对0.313）。
结论
M1分叉前段的形态与大脑中动脉粥样硬化性狭窄有关。
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