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痴呆症行为和心理症状的管理:对欧洲指南和文献的实用范围审查

Management of behavioural and psychological symptoms of dementia: a pragmatic scoping review of European guidelines and literature.

作者信息

Coin Alessandra, Brew-Girard Elsa, Tracey Ellen, Frisardi Vincenza, Piccione Federica, Muraro Costanza, Mizzon Eleonora, Shenkin Susan D, Soysal Pinar, Welsh Tomas, Roitto Hanna-Maria

机构信息

Geriatrics Division, Department of Medicine (DIMED), Azienda Ospedale-Università Padova, University of Padova, Padova, Italy.

Avon and Wiltshire Mental Health Partnership, Bath, UK.

出版信息

Eur Geriatr Med. 2025 Feb 19. doi: 10.1007/s41999-025-01155-6.

Abstract

PURPOSE

Dementia prevalence within the European Union (EU) is expected to double by 2050. Behavioural and Psychological Symptoms of Dementia (BPSD) are common, causing burden to patients and caregivers. This pragmatic scoping review aims to synthesize recommendations of European BPSD management guidelines and literature, highlighting areas of consensus and disagreement.

METHODS

An electronic literature search, including Medline, PsychINFO, and CINAHL, and Internet search for grey literature were undertaken to identify published BPSD guidelines from the EU, European Economic Area (EEA) and UK, supplemented by contacting EU member countries of European Geriatric Medicine Society (EuGMS).

RESULTS

The literature search found 11 papers describing BPSD management. Of the 32 countries of interest, 22 guidelines were sourced (five confirmed no guidelines, five did not respond). There was a general consensus between the guidelines, as all recommended comprehensive assessment and individualised approaches, with non-pharmacological therapies as first line, but there was disagreement around specific therapies. Psycho-education was most commonly recommended (15 countries). There was general agreement that pharmacological treatment should be used as an adjunct to non-pharmacological interventions, but recommendations differed between medication groups. Short-term atypical antipsychotics were most commonly recommended, especially risperidone (18 countries). 15 countries recommended acetylcholinesterase inhibitors and 12 memantine. 16 countries recommended the use of SSRIs. Recommendations for the use of sedative medications and antiepileptics varied.

CONCLUSIONS

This study provides a broad, inclusive overview of current European guidelines for the management of BPSD, demonstrating significant variability. Clinical practice in dementia care throughout Europe needs to be optimised and standardised.

摘要

目的

预计到2050年,欧盟(EU)内的痴呆症患病率将翻倍。痴呆症的行为和心理症状(BPSD)很常见,给患者和护理人员带来负担。这项务实的范围综述旨在综合欧洲BPSD管理指南和文献的建议,突出共识和分歧领域。

方法

进行电子文献检索,包括Medline、PsychINFO和CINAHL,并在互联网上搜索灰色文献,以识别来自欧盟、欧洲经济区(EEA)和英国已发表的BPSD指南,并通过联系欧洲老年医学学会(EuGMS)的欧盟成员国进行补充。

结果

文献检索发现11篇描述BPSD管理的论文。在32个感兴趣的国家中,获取了22份指南(5个国家确认没有指南,5个国家未回复)。指南之间存在普遍共识,因为所有指南都推荐综合评估和个体化方法,以非药物治疗作为一线治疗,但在具体治疗方法上存在分歧。心理教育是最常被推荐的(15个国家)。普遍认为药物治疗应作为非药物干预的辅助手段,但不同药物组的建议有所不同。短期非典型抗精神病药物是最常被推荐的药物,尤其是利培酮(18个国家)。15个国家推荐使用乙酰胆碱酯酶抑制剂,12个国家推荐使用美金刚。16个国家推荐使用选择性血清素再吸收抑制剂(SSRI)。关于使用镇静药物和抗癫痫药物的建议各不相同。

结论

本研究对当前欧洲BPSD管理指南进行了广泛、全面的概述,显示出显著的差异。欧洲各地痴呆症护理的临床实践需要优化和标准化。

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