Hassold T, Chiu D
Hum Genet. 1985;70(1):11-7. doi: 10.1007/BF00389450.
The effect of maternal age on the incidence of chromosomally normal spontaneous abortion and different categories of chromosome abnormality among all clinically recognized human pregnancies was evaluated. The results provide no evidence for a significant association of age with sex chromosome monosomy or polyploidy, but clearly demonstrate an effect of age on the frequency of trisomy and chromosomally normal spontaneous abortions. Estimated maternal age-specific rates of trisomy among all recognized pregnancies were calculated and suggest that a majority of oocytes of women aged 40 years and older may be aneuploid.
评估了母亲年龄对所有临床确诊的人类妊娠中染色体正常的自然流产发生率以及不同类型染色体异常的影响。结果未提供证据表明年龄与性染色体单体或多倍体之间存在显著关联，但清楚地表明年龄对三体性和染色体正常的自然流产频率有影响。计算了所有确诊妊娠中按母亲年龄估算的三体性发生率，结果表明40岁及以上女性的大多数卵母细胞可能为非整倍体。
