Ferrell F, Gray S D
Hypertension. 1985 May-Jun;7(3 Pt 1):326-32.
To determine whether age-related changes in salt preferences occur over the lifespans of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY), the same animals of each genotype were tested as juveniles, and as young and older adults. Taste preference ratios for NaCl and KCl, at concentrations from 0.001 to 1.0 M, were calculated using 24-hour, two-bottle preference tests of each salt versus distilled water. Genotype exerted a significant effect on preference for both NaCl and KCl (p less than 0.0005). At each age and across concentrations, SHR had consistently higher preferences than did WKY. Few marked, age-related changes in overall preference for NaCl were noted within either strain, but juvenile and older adult SHR and WKY exhibited stronger preferences than did young adults for the higher concentrations of NaCl below the rejection threshold (p less than 0.001). Statistical age by concentration preference trends for KCl were similar to those for NaCl in SHR. Young adult WKY, however, had a significantly lower rejection threshold for that compound than did juveniles and older adults (p less than 0.001). These results indicate that genotype, age, salt type, and salt concentration can interact to influence salt preference in hypertension.
为了确定盐偏好方面与年龄相关的变化是否会在自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）的整个生命周期中出现，对每种基因型的相同动物在幼年、青年和老年时进行了测试。使用每种盐与蒸馏水的24小时双瓶偏好测试，计算了浓度从0.001到1.0 M的NaCl和KCl的味道偏好比率。基因型对NaCl和KCl的偏好均产生了显著影响（p小于0.0005）。在每个年龄组以及不同浓度下，SHR的偏好始终高于WKY。在这两个品系中，均未观察到NaCl总体偏好方面明显的、与年龄相关的变化，但幼年和老年的SHR及WKY比青年大鼠对低于排斥阈值的较高浓度NaCl表现出更强的偏好（p小于0.001）。SHR中KCl的统计年龄与浓度偏好趋势与NaCl相似。然而，青年WKY对该化合物的排斥阈值明显低于幼年和老年WKY（p小于0.001）。这些结果表明，基因型、年龄、盐类型和盐浓度可以相互作用，影响高血压患者的盐偏好。
