Steiner Katharina M, Nicksirat Seyed Ali, Thieme Andreas, Müntefering Lara, Ernst Thomas M, Timmann Dagmar, Batsikadze Giorgi
Department of Neurology and Center for Translational Neuro and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany.
LVR-University-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Brain Behav. 2025 Feb;15(2):e70364. doi: 10.1002/brb3.70364.
Cerebellar brain inhibition (CBI) is a way to quantify the cerebellar influence on the motor cortex in humans. Studies suggest that the orientation of the transcranial magnetic stimulation (TMS) coil influences which motor networks are activated. This study investigated the influence of cerebellar transcranial direct current stimulation (ctDCS) on CBI as a function of coil orientation (anterior-posterior [AP] vs. posterior-anterior [PA]). An interstimulus interval (ISI) of 7 ms (CBI-AP-7) was used for AP orientation and 5 ms (CBI-PA-5) for PA orientation.
Young and healthy participants received anodal, cathodal, or sham ctDCS treatment for 15 min on three different days. On each day, CBI was determined for both coil positions immediately after and 30, 60, and 120 min after ctDCS application.
For CBI-PA-5, no significant ctDCS effect was detected. For CBI-AP-7, there was an increase in CBI by anodal ctDCS and a decrease in CBI by cathodal ctDCS, although the latter did not reach statistical significance.
Findings provide further support that different cerebello-cerebral motor networks may be activated in CBI-AP-7 and CBI-PA-5, with only CBI-AP-7 being significantly affected by ctDCS. CBI-AP-7 may be a more sensitive tool for investigating CBI effects than the CBI-PA-5 procedure, which is most commonly used.
小脑脑抑制（CBI）是一种量化小脑对人类运动皮层影响的方法。研究表明，经颅磁刺激（TMS）线圈的方向会影响激活哪些运动网络。本研究调查了小脑经颅直流电刺激（ctDCS）对CBI的影响，该影响是线圈方向（前后[AP]与后前[PA]）的函数。对于AP方向，使用7毫秒的刺激间隔（ISI）（CBI-AP-7），对于PA方向，使用5毫秒（CBI-PA-5）。
年轻健康的参与者在三天内接受阳极、阴极或假ctDCS治疗15分钟。在每一天，在ctDCS应用后立即以及应用后30、60和120分钟，对两个线圈位置测定CBI。
对于CBI-PA-5，未检测到显著的ctDCS效应。对于CBI-AP-7，阳极ctDCS使CBI增加，阴极ctDCS使CBI降低，尽管后者未达到统计学显著性。
研究结果进一步支持，在CBI-AP-7和CBI-PA-5中可能激活不同的小脑-大脑运动网络，只有CBI-AP-7受ctDCS显著影响。与最常用的CBI-PA-5程序相比，CBI-AP-7可能是研究CBI效应更敏感的工具。
