Kleinschmidt J, Römmelt H, Zuber A
Int J Clin Pharmacol Ther Toxicol. 1985 Apr;23(4):200-3.
Blood concentrations of the terpenes myrtenal, myrtenol, pionocarveol, verbenon and terbinhydrate in ozothin were investigated as a function of time after intravenous injection of 10 ml ozothin in 36 subjects. On each occasion 10 ml of the terpene mixture was injected into the inside right elbow. During the first 60 minutes after injection several 7 ml samples of citrate blood were withdrawn from the inside left elbow, immediately spun down and analysed by gas chromatography. Elimination of the terpenes from the blood during the first 10 minutes after injection appeared to follow a half-life time of three to four minutes with a second half-life time of 60 to 65 minutes. The concentration of these terpenes in expired air was determined in 27 subjects. Approximately 7% of the substances were eliminated via the lungs during the first 60 minutes. In a further series of experiments the concentration in subcutaneous fat during the first 24 hours after injection was studied. The whole terpenes concentrations range from 2.4 ng terpenes/g fat tissue to 0.8 ng terpenes/g fat at 24 hours.
在36名受试者静脉注射10毫升奥索辛后，研究了奥索辛中萜类化合物桃金娘醛、桃金娘醇、派诺蒈醇、马鞭草烯酮和萜品醇的血药浓度随时间的变化情况。每次将10毫升萜类混合物注入右肘内侧。注射后的前60分钟内，从左肘内侧抽取几管7毫升的枸橼酸盐血样，立即离心并通过气相色谱法进行分析。注射后最初10分钟内，萜类化合物从血液中的消除似乎呈现出3至4分钟的半衰期，随后还有60至65分钟的第二个半衰期。测定了27名受试者呼出气体中这些萜类化合物的浓度。在最初60分钟内，约7%的物质通过肺部排出。在另一系列实验中，研究了注射后最初24小时内皮下脂肪中的浓度。24小时时，萜类化合物在脂肪组织中的总浓度范围为2.4纳克萜类化合物/克脂肪组织至0.8纳克萜类化合物/克脂肪。
