Rezk Mohamed M
Isotopes Department, Research sector, Nuclear Materials Authority, Cairo, Egypt.
Environ Anal Health Toxicol. 2024 Dec;39(4):e2024026-0. doi: 10.5620/eaht.2024026. Epub 2024 Nov 8.
Boric acid (BA) is a weak acid and the simplest compound resulting from the dissolution of boron in water. There is great competition to determine whether boron is an essential or nonessential nutrient. Date molasses is a potent type of sweetener with valuable components, such as flavonoids and phenolics, and has significant health benefits. This study investigated the neuro-essentiality and neurotoxicity of boric acid boron in adult male albino rat cortex and cerebellum brain areas and the impact of date molasses treatment. Animals were grouped into the following groups: control, low and high boric acid doses, 10 and 500 mg/kg, respectively, with or without 250 mg/kg date molasses. The results revealed the ability of BAs to cross the blood-brain barrier and accumulate in the cerebellum and cortex, revealing the ability of date molasses to decrease BA accumulation at different time intervals. Additionally, the results varied between a nonsignificant increase or decrease in calcium ion content, monoamines (norepinephrine, dopamine, and serotonin), glucose, adenosine triphosphate, malondialdehyde and glutathione, depending on the BA dose. Moreover, date molasses mitigated any unwanted BA results. In conclusion, boric acid, which is within a permissible limit, could be essential and have a neuroprotective effect, whereas at a sublethal level, it could have a neurotoxic effect. Additionally, Date molasses can have neuroprotective effects and antagonize the neurotoxic effects of boric acid through its antioxidant and scavenging effects.
硼酸（BA）是一种弱酸，是硼在水中溶解形成的最简单化合物。关于硼是必需营养素还是非必需营养素存在很大争议。枣蜜是一种具有黄酮类化合物和酚类等有价值成分的强力甜味剂，对健康有显著益处。本研究调查了硼酸硼在成年雄性白化大鼠皮质和小脑脑区的神经必需性和神经毒性以及枣蜜处理的影响。动物被分为以下几组：对照组、低剂量和高剂量硼酸组，分别为10和500毫克/千克，有或没有250毫克/千克枣蜜。结果显示硼酸能够穿过血脑屏障并在小脑和皮质中积累，表明枣蜜在不同时间间隔有降低硼酸积累的能力。此外，根据硼酸剂量不同，钙离子含量、单胺类物质（去甲肾上腺素、多巴胺和5-羟色胺）、葡萄糖、三磷酸腺苷、丙二醛和谷胱甘肽的含量有不显著的增加或减少。而且，枣蜜减轻了任何不良的硼酸结果。总之，在允许限度内的硼酸可能是必需的且具有神经保护作用，而在亚致死水平时，它可能具有神经毒性作用。此外，枣蜜可通过其抗氧化和清除作用具有神经保护作用并拮抗硼酸的神经毒性作用。
