Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Rd., Worcester, MA 01609, U.S.A.
Biochem Soc Trans. 2024 Apr 24;52(2):937-945. doi: 10.1042/BST20231518.
Calcium is a primary second messenger that plays a role in cellular functions including growth, movement and responses to drugs. The role that calcium plays in mediating communication between neurons by synaptic vesicle release is well established. This review focuses on the dependence of the physical properties of neuronal plasma membranes on calcium levels. After describing the key features of synaptic plasticity, we summarize the general role of calcium in cell function and the signaling pathways responsible for intracellular increase in calcium levels. We then present findings showing that increases in intracellular calcium levels cause neurites to contract and break synaptic connections by changes in membrane tension.
钙是一种主要的第二信使，在细胞功能中发挥作用，包括生长、运动和对药物的反应。钙在介导神经元之间通过突触小泡释放的通讯中的作用已得到充分证实。这篇综述主要关注神经元质膜的物理性质对钙水平的依赖性。在描述突触可塑性的关键特征后，我们总结了钙在细胞功能中的一般作用以及负责细胞内钙水平升高的信号通路。然后，我们提出了一些发现，表明细胞内钙水平的升高会通过膜张力的变化导致轴突收缩和破坏突触连接。
