Pirozzolo F J, Mahurin R K, Loring D W, Appel S H, Maletta G J
Int J Neurosci. 1985 Apr;26(1-2):1-7. doi: 10.3109/00207458508985597.
The effects of cognitive impairment resulting from either dementia of the Alzheimer type (DAT) or major depression (pseudodementia) on choice reaction time were examined in two conditions hypothesized to influence group performance selectively. Elderly controls had shorter reaction times than depressed patients who, in turn, were faster than dementia patients in the standard choice reaction time test. Elderly control and depressed subjects responded more quickly under conditions designed to reduce task demands. However, no effect was detected for DAT patients, presumably due to the neural constraints imposed on cognitive functioning in dementia. These results highlight the different etiologies for the intellectual decline in dementia and pseudodementia.
在两种假设会选择性影响组间表现的条件下，研究了由阿尔茨海默病型痴呆（DAT）或重度抑郁症（假性痴呆）导致的认知障碍对选择反应时的影响。在标准选择反应时测试中，老年对照组的反应时比抑郁症患者短，而抑郁症患者又比痴呆症患者反应快。在旨在降低任务要求的条件下，老年对照组和抑郁症受试者反应更快。然而，未检测到DAT患者有此效应，可能是由于痴呆症对认知功能施加的神经限制。这些结果突出了痴呆症和假性痴呆智力衰退的不同病因。
