Mino M, Kasugai O, Nagita A
Int J Vitam Nutr Res. 1985;55(1):47-51.
As the assessment of the nutritional status of vitamin E, the validity of red blood cell (RBC) tocopherol concentration was examined in relation to tocopherol concentration in the liver and in its subcellular fractions. When 10 mg/kg of dl-alpha-tocopherol was injected intramuscularly to vitamin E deficient rats, plasma tocopherol reached a maximum level earlier than did RBC tocopherol and liver tocopherol. However, as the correlation in tocopherol concentrations between RBC and plasma and between RBC and tissue homogenate or its subcellular fractions was examined with respect to all the values examines during the study courses, a moderately close correlation was observed between RBC and liver tissue and between RBC and the subcellular fractions while a lack of correlation was found between RBC and plasma. When rats sufficient in vitamin E were depleted for 8 weeks by a vitamin E deficient diet, tocopherol concentrations decreased in a similar pattern in the plasma, RBC, and liver and its subcellular fractions. In this case, a very close correlation in the tocopherol concentrations was observed between RBC and other subjects, i.e., the plasma, liver homogenate and its subcellular fractions.
作为维生素E营养状况的评估，研究了红细胞（RBC）生育酚浓度与肝脏及其亚细胞组分中生育酚浓度之间的相关性。当向维生素E缺乏的大鼠肌肉注射10mg/kg的dl-α-生育酚时，血浆生育酚比红细胞生育酚和肝脏生育酚更早达到最高水平。然而，在研究过程中对所有检测值进行分析时，红细胞与血浆之间、红细胞与组织匀浆或其亚细胞组分之间的生育酚浓度相关性研究发现，红细胞与肝脏组织以及红细胞与亚细胞组分之间存在中等程度的密切相关性，而红细胞与血浆之间缺乏相关性。当用维生素E缺乏的饮食使维生素E充足的大鼠耗尽8周时，血浆、红细胞、肝脏及其亚细胞组分中的生育酚浓度以相似的模式下降。在这种情况下，观察到红细胞与其他指标（即血浆、肝脏匀浆及其亚细胞组分）之间的生育酚浓度存在非常密切的相关性。
