Hages M, Pietrzik K
Int J Vitam Nutr Res. 1985;55(1):69-77.
In a study with 165 children the folate, cobalamin and iron status was investigated by biochemical and haematological methods. On the basis of biologically based borderlines it could be demonstrated, that 15% of the children showed folate deficiency in a progressive state. This means that low serum resp. low erythrocytic folate concentrations correlated with alterations in the blood picture (lobe average of the neutrophilic granulocytes). Especially children in the age of puberty (11-15 years) are to be regarded as vulnerable; 30% of this group show deficiency symptoms whereas in very young children (1-5 years) only in 10% the supply situation is insufficient. The folate status in pupils (6-10 years) is comparable to adults (15% deficient). As cobalamin and iron status may influence folate depending parameters the status of these nutrients was estimated, too. Cobalamin deficiency was not detectable in any case. Though the iron supply situation was not adequate in all cases, interactions with the folate depending parameters could be excluded.
在一项针对165名儿童的研究中，通过生化和血液学方法对叶酸、钴胺素和铁的状况进行了调查。根据基于生物学的临界值可以证明，15%的儿童表现出处于进展状态的叶酸缺乏。这意味着血清叶酸水平低或红细胞叶酸浓度低与血象变化（中性粒细胞的叶平均）相关。特别是青春期（11 - 15岁）的儿童被认为是易患群体；该组中有30%表现出缺乏症状，而在幼儿（1 - 5岁）中只有10%的供应情况不足。小学生（6 - 10岁）的叶酸状况与成年人相当（15%缺乏）。由于钴胺素和铁的状况可能会影响依赖叶酸的参数，因此也对这些营养素的状况进行了评估。在任何情况下都未检测到钴胺素缺乏。虽然并非所有情况下铁的供应状况都充足，但可以排除与依赖叶酸的参数之间的相互作用。
