Hages M, Pietrzik K
Int J Vitam Nutr Res. 1985;55(1):59-67.
The biochemical data concerning the evaluation of the folacin status in children are insufficient, as there are no biologically based borderlines available. In a study with 165 children between 1 and 15 years we looked for serum and erythrocytic folate concentrations and correlated the results with morphological alterations in the blood picture (lobe average of the neutrophilic granulocytes). As cobalamin and iron status influences different folacin depending parameters we estimated the vitamin B12- and ferritin concentration in serum as well. In our study neither the iron nor the cobalamin status influenced the blood picture and the blood folate concentrations. That's why all samples could be taken for the final evaluation. It could be demonstrated that folacin serum levels below 4.0 ng/ml respectively erythrocytic concentrations below 250 ng/ml correspond with an increasing lobe average above 3.5 compared with normal values ranging between 2.8-3.5. These biologically based borderlines were comparable between the different age groups. On the basis of these data it is possible to assess the duration and severity of folacin deficiency in children.
关于评估儿童叶酸状态的生化数据不足，因为没有基于生物学的临界值。在一项针对165名1至15岁儿童的研究中，我们检测了血清和红细胞叶酸浓度，并将结果与血液图片中的形态学改变（中性粒细胞的叶平均数）相关联。由于钴胺素和铁状态会影响不同的叶酸相关参数，我们还估算了血清中的维生素B12和铁蛋白浓度。在我们的研究中，铁状态和钴胺素状态均未影响血液图片和血液叶酸浓度。因此，所有样本都可用于最终评估。结果表明，与正常范围在2.8 - 3.5之间的值相比，血清叶酸水平低于4.0 ng/ml或红细胞浓度低于250 ng/ml时，叶平均数会增加至高于3.5。这些基于生物学的临界值在不同年龄组之间具有可比性。基于这些数据，可以评估儿童叶酸缺乏的持续时间和严重程度。
