Sumowski James F, Levy Sarah
Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology, Icahn School of Medicine at Mount Sinai.
medRxiv. 2025 Feb 7:2025.02.06.25321807. doi: 10.1101/2025.02.06.25321807.
Patient-reported outcomes importantly reflect the lived experiences of persons with multiple sclerosis (MS); however, given the broad array of MS symptoms, comprehensive evaluation can be burdensome, especially with lengthy questionnaires. The MS Impact Scale queries twenty different physical difficulties (MSIS-20). In 1150 patients with MS, evaluation of internal consistency indicated redundancy in the MSIS-20 (Cronbach's alpha: 0.96), but optimal internal consistency (0.90) of a six-item short form (MSIS-SF; first six MSIS items). The MSIS-20 and MSIS-SF showed comparably strong associations with objective physical disability. The MSIS-SF provides a psychometrically robust, less burdensome, and time-efficient option for assessing patient-reported physical disturbance.
患者报告的结果能重要地反映多发性硬化症（MS）患者的实际生活体验；然而，鉴于MS症状种类繁多，全面评估可能会很繁琐，尤其是使用冗长的问卷时。MS影响量表询问了20种不同的身体困难（MSIS - 20）。在1150例MS患者中，内部一致性评估表明MSIS - 20存在冗余（克朗巴赫α系数：0.96），而一个六项简短形式（MSIS - SF；MSIS的前六项）具有最佳的内部一致性（0.90）。MSIS - 20和MSIS - SF与客观身体残疾显示出相当强的关联。MSIS - SF为评估患者报告的身体不适提供了一种心理测量稳健、负担较小且省时的选择。
