Charytoniuk Tomasz, Półjanowski Stanisław, Michalak Mateusz, Kaźmierczak Karolina, Kałużny Bartłomiej
Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Front Med (Lausanne). 2025 Feb 5;12:1500179. doi: 10.3389/fmed.2025.1500179. eCollection 2025.
Within the last decade the role of the endocannabinoid system (ECS) has been a significant part of ophthalmic research, including both ocular physiology and the development of eye pathologies. It is known that this widespread cell-signaling system is involved in retinal neurobiological processes, including visual signal processing, as well as neurotransmission. Furthermore, various research indicated the involvement of ECS in the molecular basis of various pathologies, mostly glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD). Therefore, the researchers believe that this biological system, its receptors, pathways, and ligands might be considered as an auxiliary compound to reduce the number of patients suffering from ophthalmic diseases. Despite presented in the literature effects of the endocannabinoid system in the eye, none of the current ECS reviews presented a comprehensive description of the endocannabinoid system, its compounds, and, subsequently ophthalmic disorders. Thus, the aim of this review was to summarize all the major data, including the most up-to-date research, concerning a correlation between the endocannabinoid system and the major ophthalmic pathologies.
在过去十年中，内源性大麻素系统（ECS）的作用一直是眼科研究的重要组成部分，涵盖了眼生理学和眼部病理学的发展。众所周知，这种广泛存在的细胞信号系统参与视网膜神经生物学过程，包括视觉信号处理以及神经传递。此外，各种研究表明ECS参与了多种病理学的分子基础，主要是青光眼、糖尿病视网膜病变和年龄相关性黄斑变性（AMD）。因此，研究人员认为，这个生物系统、其受体、途径和配体可能被视为一种辅助化合物，以减少患有眼科疾病的患者数量。尽管文献中介绍了内源性大麻素系统在眼部的作用，但目前没有一篇关于ECS的综述对该系统、其化合物以及随后的眼科疾病进行全面描述。因此，本综述的目的是总结所有主要数据，包括最新研究，以探讨内源性大麻素系统与主要眼科病理学之间的相关性。
