• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

芜湖汤通过Th1/Th2失衡影响哮喘进展的治疗效力及可能机制

Therapeutic potency and possible mechanism of Wuhu decoction underlying asthmatic progression via Th1/Th2 imbalance.

作者信息

Hu Yan, Wang Mengqing, Luo Yinhe, Xie Jing, Jiao Luojia, Tang Wei, Deng Yijue, Yao Bing

机构信息

Department of Pediatrics, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China.

Teaching and Research Office of Chinese and Western Combination, Hunan University of Chinese Medicine, Changsha, China.

出版信息

J Thorac Dis. 2025 Jan 24;17(1):265-277. doi: 10.21037/jtd-24-804. Epub 2025 Jan 22.

DOI:10.21037/jtd-24-804
PMID:39975754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11833591/
Abstract

BACKGROUND

Cough variant asthma (CVA) is a disease with no definitive diagnosis or pathogenic causes, and still lacks effective and safe treatment. Wuhu decoction is a traditional Chinese medicine with potential effects against CVA, of which underlying mechanism remains elusive. The aim of this study is to explore the therapeutic potential of Wuhu decoction against CVA.

METHODS

The CVA mice model was established by ovalbumin (OVA) treatment. The airway hyperresponsiveness and remodeling were assessed. The pulmonary inflammatory injury was determined by counting of inflammatory cells and serum OVA-specific immunoglobulin E (IgE) in bronchoalveolar lavage fluid, as well as the amount of CD4, CD8 or CD25 T cells. The Th1/Th2 balance was evaluated by type specific cytokines. The level of antisense long non-coding RNA TRPM2 (lncTRPM2-AS) and its downstream targets were determined by mRNA and protein detection, respectively.

RESULTS

Wuhu decoction could improve airway hyperresponsiveness and remodeling in OVA-induced asthmatic mice model by regulating Th1/Th2 balance and affecting pulmonary inflammatory injury. On the molecular level, Wuhu decoction significantly inhibited the expression of lncTRPM2-AS, which was found to be a critical modulator of Th1/Th2 balance. Meanwhile, overexpression of lncTRPM2-AS could abolish Wuhu decoction-mediated protection effects on OVA-induced asthmatic mice model.

CONCLUSIONS

This study discovered the protective function of Wuhu decoction against CVA and illustrated its molecular mechanism, highlighting the therapeutic application of Wuhu decoction for asthma treatment.

摘要

背景

咳嗽变异性哮喘（CVA）是一种诊断不明确且病因不明的疾病，仍然缺乏有效且安全的治疗方法。五胡汤是一种对CVA可能有潜在疗效的中药，但其潜在机制仍不清楚。本研究的目的是探讨五胡汤对CVA的治疗潜力。

方法

通过卵清蛋白（OVA）处理建立CVA小鼠模型。评估气道高反应性和重塑情况。通过计数支气管肺泡灌洗液中的炎性细胞和血清OVA特异性免疫球蛋白E（IgE）以及CD4、CD8或CD25 T细胞的数量来确定肺部炎性损伤。通过特定类型的细胞因子评估Th1/Th2平衡。分别通过mRNA和蛋白质检测来确定反义长链非编码RNA TRPM2（lncTRPM2-AS）及其下游靶点的水平。

结果

五胡汤可通过调节Th1/Th2平衡并影响肺部炎性损伤来改善OVA诱导的哮喘小鼠模型中的气道高反应性和重塑。在分子水平上，五胡汤显著抑制lncTRPM2-AS的表达，发现其是Th1/Th2平衡的关键调节因子。同时，lncTRPM2-AS的过表达可消除五胡汤对OVA诱导的哮喘小鼠模型的保护作用。

结论

本研究发现了五胡汤对CVA的保护作用并阐明了其分子机制，突出了五胡汤在哮喘治疗中的治疗应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/f8346fb3008a/jtd-17-01-265-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/ff3b9a6abf12/jtd-17-01-265-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/966d67e391fe/jtd-17-01-265-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/1d8ba914dfa7/jtd-17-01-265-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/d1ac4fa44af1/jtd-17-01-265-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/8d75bbae86ca/jtd-17-01-265-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/e2464f8dcf6f/jtd-17-01-265-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/f8346fb3008a/jtd-17-01-265-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/ff3b9a6abf12/jtd-17-01-265-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/966d67e391fe/jtd-17-01-265-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/1d8ba914dfa7/jtd-17-01-265-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/d1ac4fa44af1/jtd-17-01-265-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/8d75bbae86ca/jtd-17-01-265-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/e2464f8dcf6f/jtd-17-01-265-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baea/11833591/f8346fb3008a/jtd-17-01-265-f7.jpg

相似文献

1
Therapeutic potency and possible mechanism of Wuhu decoction underlying asthmatic progression via Th1/Th2 imbalance.芜湖汤通过Th1/Th2失衡影响哮喘进展的治疗效力及可能机制
J Thorac Dis. 2025 Jan 24;17(1):265-277. doi: 10.21037/jtd-24-804. Epub 2025 Jan 22.
2
Therapeutic effects and mechanisms study of Hanchuan Zupa Granule in a Guinea pig model of cough variant asthma.汉川止嗽颗粒对豚鼠咳嗽变异性哮喘模型的治疗作用及机制研究。
J Ethnopharmacol. 2021 Apr 6;269:113719. doi: 10.1016/j.jep.2020.113719. Epub 2020 Dec 28.
3
Wuhu Decoction Regulates Dendritic Cell Autophagy in the Treatment of Respiratory Syncytial Virus (RSV)-Induced Mouse Asthma by AMPK/ULK1 Signaling Pathway.芜湖汤通过 AMPK/ULK1 信号通路调节树突状细胞自噬治疗呼吸道合胞病毒（RSV）诱导的小鼠哮喘
Med Sci Monit. 2019 Jul 20;25:5389-5400. doi: 10.12659/MSM.917692.
4
Effect of San'ao decoction with scorpio and bombyx batryticatus on CVA mice model via airway inflammation and regulation of TRPA1/TRPV1/TRPV5 channels.三拗汤加蝎蜈对 CVA 小鼠模型气道炎症及 TRPA1/TRPV1/TRPV5 通道的调控作用。
J Ethnopharmacol. 2021 Jan 10;264:113342. doi: 10.1016/j.jep.2020.113342. Epub 2020 Sep 3.
5
[Active components and mechanism of Wuhu Decoction in intervening RSV-induced asthma based on network pharmacology and in vivo experiment].基于网络药理学和体内实验探讨芜湖汤干预呼吸道合胞病毒诱导哮喘的活性成分及作用机制
Zhongguo Zhong Yao Za Zhi. 2024 Aug;49(15):4148-4157. doi: 10.19540/j.cnki.cjcmm.20240411.406.
6
Zi-Su-Zi decoction improves airway hyperresponsiveness in cough-variant asthma rat model through PI3K/AKT1/mTOR, JAK2/STAT3 and HIF-1α/NF-κB signaling pathways.自拟子滋汤通过 PI3K/AKT1/mTOR、JAK2/STAT3 和 HIF-1α/NF-κB 信号通路改善咳嗽变异性哮喘大鼠模型的气道高反应性。
J Ethnopharmacol. 2023 Oct 5;314:116637. doi: 10.1016/j.jep.2023.116637. Epub 2023 May 13.
7
Bulleyaconitine A inhibits the lung inflammation and airway remodeling through restoring Th1/Th2 balance in asthmatic model mice.布列亚乌头碱A通过恢复哮喘模型小鼠的Th1/Th2平衡来抑制肺部炎症和气道重塑。
Biosci Biotechnol Biochem. 2020 Jul;84(7):1409-1417. doi: 10.1080/09168451.2020.1752140. Epub 2020 Apr 14.
8
Exposure to ephedrine attenuates Th1/Th2 imbalance underlying OVA-induced asthma through airway epithelial cell-derived exosomal lnc-TRPM2-AS.暴露于麻黄碱可通过气道上皮细胞衍生的外泌体 lnc-TRPM2-AS 减轻 OVA 诱导的哮喘中的 Th1/Th2 失衡。
Chin J Nat Med. 2024 Jun;22(6):530-540. doi: 10.1016/S1875-5364(24)60554-6.
9
Pheretima aspergillum decoction suppresses inflammation and relieves asthma in a mouse model of bronchial asthma by NF-κB inhibition.地龙汤通过抑制NF-κB在支气管哮喘小鼠模型中发挥抗炎和缓解哮喘的作用。
J Ethnopharmacol. 2016 Aug 2;189:22-30. doi: 10.1016/j.jep.2016.05.028. Epub 2016 May 13.
10
Study on the Relationship Between Bronchoalveolar Lavage Fluid Cell Count, Th1/Th2 Cytokines and Pulmonary Function in Patients with Cough Variant Asthma.咳嗽变异性哮喘患者支气管肺泡灌洗液细胞计数、Th1/Th2细胞因子与肺功能的关系研究
J Asthma Allergy. 2022 Nov 24;15:1713-1720. doi: 10.2147/JAA.S383128. eCollection 2022.

本文引用的文献

1
Wuhu decoction combined with azithromycin for treatment of pneumoniae pneumonia in Asian children: a systematic review and meta analysis of randomized controlled trials.芜湖汤联合阿奇霉素治疗亚洲儿童肺炎支原体肺炎：一项随机对照试验的系统评价和荟萃分析
Front Pharmacol. 2024 Apr 3;15:1329516. doi: 10.3389/fphar.2024.1329516. eCollection 2024.
2
Mechanistic analysis of Th2-type inflammatory factors in asthma.哮喘中Th2型炎症因子的机制分析
J Thorac Dis. 2023 Dec 30;15(12):6898-6914. doi: 10.21037/jtd-23-1628. Epub 2023 Dec 26.
3
Biologics and airway remodeling in severe asthma.
生物制剂与重症哮喘中的气道重塑。
Allergy. 2022 Dec;77(12):3538-3552. doi: 10.1111/all.15473. Epub 2022 Aug 23.
4
LncTRPM2-AS inhibits TRIM21-mediated TRPM2 ubiquitination and prevents autophagy-induced apoptosis of macrophages in asthma.长链非编码 RNA-TRPM2-AS 抑制 TRIM21 介导的 TRPM2 泛素化，防止哮喘中巨噬细胞自噬诱导的细胞凋亡。
Cell Death Dis. 2021 Dec 13;12(12):1153. doi: 10.1038/s41419-021-04437-6.
5
Th17/Treg imbalance is associated with reduced indoleamine 2,3 dioxygenase activity in childhood allergic asthma.Th17/调节性T细胞失衡与儿童过敏性哮喘中吲哚胺2,3-双加氧酶活性降低有关。
Allergy Asthma Clin Immunol. 2020 Jul 7;16:61. doi: 10.1186/s13223-020-00457-7. eCollection 2020.
6
lncRNA PCGEM1 strengthens anti-inflammatory and lung protective effects of montelukast sodium in children with cough-variant asthma.lncRNA PCGEM1 增强孟鲁司特钠对咳嗽变异性哮喘患儿的抗炎和肺保护作用。
Braz J Med Biol Res. 2020 Jun 5;53(7):e9271. doi: 10.1590/1414-431X20209271. eCollection 2020.
7
Wuhu Decoction Regulates Dendritic Cell Autophagy in the Treatment of Respiratory Syncytial Virus (RSV)-Induced Mouse Asthma by AMPK/ULK1 Signaling Pathway.芜湖汤通过 AMPK/ULK1 信号通路调节树突状细胞自噬治疗呼吸道合胞病毒（RSV）诱导的小鼠哮喘
Med Sci Monit. 2019 Jul 20;25:5389-5400. doi: 10.12659/MSM.917692.
8
Long Noncoding RNA: Genomics and Relevance to Physiology.长链非编码 RNA：基因组学及其与生理学的相关性。
Compr Physiol. 2019 Jun 12;9(3):933-946. doi: 10.1002/cphy.c180032.
9
Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: Relevance to the Th1/Th2 cytokines and STAT6/T-bet.口服保加利亚乳杆菌 N45.10 抑制变应性哮喘小鼠的肺部炎症和气道重塑：与 Th1/Th2 细胞因子和 STAT6/T-bet 的关系。
Cell Immunol. 2019 Jul;341:103928. doi: 10.1016/j.cellimm.2019.103928. Epub 2019 May 23.
10
Chinese herbal medicine for the treatment of cough variant asthma: a study protocol for a double-blind randomized controlled trial.中药治疗咳嗽变异性哮喘：一项双盲随机对照试验的研究方案
Trials. 2019 Jan 3;20(1):3. doi: 10.1186/s13063-018-3073-x.