聚焦铜耗竭诱导的铜死亡用于癌症治疗。
A focus on copper depletion-induced cuproptosis for cancer therapy.
作者信息
Zhang Hongjie
机构信息
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Jilin Changchun 130022 China
Department of Chemistry, Tsinghua University Beijing 100084 China.
出版信息
Chem Sci. 2025 Feb 18;16(10):4192-4194. doi: 10.1039/d5sc90034d. eCollection 2025 Mar 5.
Copper has emerged as a promising target for cancer therapy, with extensive studies on copper accumulation-induced cuproptosis. However, the potential of copper depletion-induced cuproptosis remains largely unexplored. Recently, Zhou (M. Zhou, F. Muhammad, Y. Zhang, T. Li, J. Feng, J. Zhao and H. Wei, , 2025, https://doi.org/10.1039/D4SC04712E) reported an innovative strategy for copper depletion-based cuproptosis. Notably, this approach leverages the solubility product principle, a mechanism not previously addressed in studies, to achieve effective tumor therapy through the disruption of copper homeostasis.
铜已成为癌症治疗的一个有前景的靶点，针对铜积累诱导的铜死亡已有广泛研究。然而，铜耗竭诱导的铜死亡的潜力在很大程度上仍未被探索。最近，周（M. Zhou、F. Muhammad、Y. Zhang、T. Li、J. Feng、J. Zhao和H. Wei，，2025，https://doi.org/10.1039/D4SC04712E）报道了一种基于铜耗竭的铜死亡创新策略。值得注意的是，该方法利用了溶解度积原理，这是此前研究中未涉及的一种机制，通过破坏铜稳态来实现有效的肿瘤治疗。
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