Xiao Fengfeng, Liu Yongkang, Su Yanhong, He Xu, Lu Ligong, Zhan Meixiao, Wen Liewei, Dai Yunlu, Liu Bing
Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Jinan University, Zhuhai, Guangdong 519000, China.
Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, China.
Chem Bio Eng. 2024 Jun 7;1(5):448-460. doi: 10.1021/cbe.4c00078. eCollection 2024 Jun 27.
Clearly delineating the tumor foci based on multimodal imaging techniques and precisely guiding the minimally invasive therapy are pivotal to completely remove tumors, especially for early micro-tumor lesions. Nevertheless, single-mode imaging techniques are difficult to accurately visualize the tumor region, and the mono-therapeutic strategy is hardly a complete removal of the tumor. In this study, we prepare a biodegradable amphiphilic polymer containing poly(aspartic acid). It is further self-assembled with Bi and ultrasmall FeO to form a multifunctional nanocomplex (Bi/FeO@P3), which served as a CT/MRI dual-imaging contrast agent and enhanced the photothermal/chemodynamic synergistic therapy. In addition, to enhance the photothermal efficiency, the thermal stress also elevated the level of intracellular HO, which would facilitate the Fenton reaction between Bi/Fe and HO and improve the chemodynamic therapy (CDT) efficacy. Particularly, Bi/FeO@P3 would concurrently deplete the abundant intracellular GSH through the coordination of Bi with GSH to further potentiate the PTT/CDT synergistic tumoricidal efficacy. Therefore, our study was expected to provide a promising theranostic nano-agent and potential comprehensive therapeutic strategy for microtumors.
基于多模态成像技术清晰地勾勒肿瘤病灶并精确引导微创治疗对于完全切除肿瘤至关重要，尤其是对于早期微肿瘤病变。然而，单模态成像技术难以准确可视化肿瘤区域，单一治疗策略也很难完全切除肿瘤。在本研究中，我们制备了一种含聚天冬氨酸的可生物降解两亲聚合物。它进一步与铋和超小的氧化亚铁自组装形成多功能纳米复合物（Bi/FeO@P3），其作为一种CT/MRI双成像造影剂，并增强光热/化学动力学协同治疗。此外，为了提高光热效率，热应力还提高了细胞内过氧化氢的水平，这将促进Bi/Fe与过氧化氢之间的芬顿反应并提高化学动力学治疗（CDT）疗效。特别地，Bi/FeO@P3会通过铋与谷胱甘肽的配位同时耗尽细胞内丰富的谷胱甘肽，以进一步增强光热治疗/化学动力学治疗协同杀肿瘤疗效。因此，我们的研究有望为微肿瘤提供一种有前景的诊疗纳米剂和潜在的综合治疗策略。
