Matsubara S, Horiuchi J, Okuyama T, Takeda M, Shibuya H, Suzuki S, Kishi K
Int J Radiat Oncol Biol Phys. 1985 Jun;11(6):1085-94. doi: 10.1016/0360-3016(85)90054-9.
In the present study, the induction efficiencies of chromosome aberrations were analyzed in patients receiving various modalities of interstitial radiotherapy with small radiation sources in the oral cavity area and compared with those in patients treated with external telecobalt irradiation in the thoracic region. Further, as a local nonstochastic effect, the acute mucosal reaction was investigated. The mucosal reaction in the area treated by brachytherapy reached a maximum at two to three weeks after the implantation. The frequencies of dicentrics plus rings of peripheral lymphocytes, on the other hand, revealed rapid increases and approached plateau levels as early as two days after the implantation. The whole-body effects, evaluated on the basis of the chromosome aberration frequencies of peripheral lymphocytes in the patients who underwent brachytherapy, were compared with the effects observed in those patients treated with external radiotherapy or bleomycin injection and discussed with regard to their effectiveness in control of the tumor and side effects. The radiation doses used in the patients who received brachytherapy or a single external irradiation were found to exert the same effects on the chromosome aberration induction. However, even in the case of brachytherapy in which whole-body side effects were believed to be trivial, the peripheral lymphocyte count was temporarily reduced to one half or less of the preirradiation level. An equivalent whole-body dose of 50 cGy was obtained from the frequencies of dicentrics and rings.
在本研究中，分析了口腔区域接受各种小放射源间质放疗方式的患者染色体畸变的诱导效率，并与胸部接受体外钴远距离照射治疗的患者进行了比较。此外，作为局部非随机效应，对急性黏膜反应进行了研究。近距离放疗区域的黏膜反应在植入后两到三周达到最大值。另一方面，外周淋巴细胞双着丝粒加环的频率在植入后两天就迅速增加并接近平台期水平。根据接受近距离放疗患者外周淋巴细胞的染色体畸变频率评估的全身效应，与接受体外放疗或博来霉素注射治疗的患者所观察到的效应进行了比较，并就其在控制肿瘤和副作用方面的有效性进行了讨论。发现接受近距离放疗或单次体外照射的患者所使用的辐射剂量对染色体畸变诱导产生相同的效应。然而，即使在认为全身副作用微不足道的近距离放疗情况下，外周淋巴细胞计数也会暂时降至照射前水平的一半或更低。从双着丝粒和环的频率得出等效全身剂量为50 cGy。
