Center S A, Baldwin B H, de Lahunta A, Dietze A E, Tennant B C
J Am Vet Med Assoc. 1985 May 15;186(10):1090-4.
The serum concentration of bile acids was measured in dogs and cats with portosystemic venous anomalies (PSVA). In 14 dogs, the mean serum bile acid concentration after 12 hours of fasting was 61.7 +/- 68.7 mumol/L (normal, 2.3 +/- 0.4 mumol/L (SEM) and when measured 2 hours after a meal in 15 dogs was 229.9 +/- 87.7 mumol/L (normal, 8.3 +/- 2.2 mumol/L). The fasting serum bile acid concentration was within the normal range in 5 of 14 dogs. The postprandial concentration was determined in 3 of the 5 and in each case increased more than tenfold above the fasting value. The mean fasting serum bile acid concentration in 4 cats was 24.4 +/- 10.1 mumol/L (normal, 1.7 +/- 0.3 mumol/L) and in 2 of the cats increased to a mean of 120.6 mumol/L (normal, 8.3 +/- 0.8 mumol/L) 2 hours after feeding. The bile acid values in patients with PSVA were correlated with values for blood ammonia content, sulfobromophthalein (BSP) retention, and results of conventional tests of hepatic function. Bile acid concentrations were more sensitive than abnormalities in serum enzyme activities or BSP retention and equal in sensitivity to the ammonia tolerance test in detecting hepatobiliary insufficiency. Bile acid measurements were accomplished with less inconvenience to the patient and clinician, than tests of BSP excretion or ammonia tolerance. Used in combination with conventional laboratory tests for hepatic disease, pre- and postprandial serum bile acid concentrations appear to be a sensitive and specific indicator of hepatobiliary dysfunction of value in the diagnosis of PSVA in the dog and cat.
对患有门体静脉异常（PSVA）的犬猫测定了血清胆汁酸浓度。14只犬在禁食12小时后的平均血清胆汁酸浓度为61.7±68.7μmol/L（正常为2.3±0.4μmol/L（标准误）），15只犬在进食后2小时测定的浓度为229.9±87.7μmol/L（正常为8.3±2.2μmol/L）。14只犬中有5只的禁食血清胆汁酸浓度在正常范围内。对这5只中的3只测定了餐后浓度，每只的餐后浓度均比禁食值增加了10倍以上。4只猫的平均禁食血清胆汁酸浓度为24.4±10.1μmol/L（正常为1.7±0.3μmol/L），其中2只猫在进食2小时后平均升至120.6μmol/L（正常为8.3±0.8μmol/L）。PSVA患者的胆汁酸值与血氨含量、磺溴酞钠（BSP）潴留值以及肝功能常规检测结果相关。在检测肝胆功能不全方面，胆汁酸浓度比血清酶活性异常或BSP潴留更敏感，与氨耐受试验的敏感性相当。与BSP排泄试验或氨耐受试验相比，胆汁酸测定给患者和临床医生带来的不便更少。与肝病的常规实验室检测相结合，餐前和餐后血清胆汁酸浓度似乎是一种敏感且特异的指标，对诊断犬猫PSVA中的肝胆功能障碍有价值。
