金霉素A和B的生物合成。发色团的起源。
Biosynthesis of chrysomycins A and B. Origin of the chromophore.
作者信息
Carter G T, Fantini A A, James J C, Borders D B, White R J
出版信息
J Antibiot (Tokyo). 1985 Feb;38(2):242-8. doi: 10.7164/antibiotics.38.242.
PMID:3997669
Abstract
The biosynthetic origin of the carbon atoms in the chromophores of chrysomycins A and B was investigated in feeding experiments using 13C labeled acetates and propionate. A biosynthetic scheme is proposed involving the condensation and rearrangement of a decaketide intermediate which contains either propionate (chrysomycin A) or acetate (chrysomycin B) as the chain initiator.
摘要
在使用13C标记的乙酸盐和丙酸盐的饲喂实验中，研究了金霉素A和B发色团中碳原子的生物合成起源。提出了一种生物合成方案，该方案涉及一种十酮中间体的缩合和重排，该中间体以丙酸盐（金霉素A）或乙酸盐（金霉素B）作为链引发剂。
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