• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Deacetoxycephalosporin C synthetase and deacetoxycephalosporin C hydroxylase are two separate enzymes in Streptomyces clavuligerus.

作者信息

Jensen S E, Westlake D W, Wolfe S

出版信息

J Antibiot (Tokyo). 1985 Feb;38(2):263-5. doi: 10.7164/antibiotics.38.263.

DOI:10.7164/antibiotics.38.263
PMID:3997672
Abstract
摘要

相似文献

1
Deacetoxycephalosporin C synthetase and deacetoxycephalosporin C hydroxylase are two separate enzymes in Streptomyces clavuligerus.去乙酰氧基头孢菌素C合成酶和去乙酰氧基头孢菌素C羟化酶是棒状链霉菌中的两种不同的酶。
J Antibiot (Tokyo). 1985 Feb;38(2):263-5. doi: 10.7164/antibiotics.38.263.
2
Purification and initial characterization of deacetoxycephalosporin C synthase from Streptomyces clavuligerus.
Can J Microbiol. 1988 Nov;34(11):1196-202. doi: 10.1139/m88-210.
3
Purification and characterization of cephalosporin 7 alpha-hydroxylase from Streptomyces clavuligerus.来自棒状链霉菌的头孢菌素7α-羟化酶的纯化与特性分析
Biochem J. 1991 Dec 1;280 ( Pt 2)(Pt 2):471-4. doi: 10.1042/bj2800471.
4
Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase.编码去乙酰氧头孢菌素C合成酶的棒状链霉菌基因在大肠杆菌中的克隆、特性鉴定及表达
J Bacteriol. 1989 Feb;171(2):754-60. doi: 10.1128/jb.171.2.754-760.1989.
5
Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium.顶头孢霉中去乙酰氧基头孢菌素C合成酶/羟化酶的共纯化及特性研究
J Bacteriol. 1987 Apr;169(4):1611-8. doi: 10.1128/jb.169.4.1611-1618.1987.
6
Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities.具有去乙酰氧基头孢菌素C合成酶和羟化酶活性的一种酶的纯化及初步表征
Biochem J. 1987 Aug 1;245(3):831-41. doi: 10.1042/bj2450831.
7
Purification and properties of deacetoxycephalosporin C synthase from recombinant Escherichia coli and its comparison with the native enzyme purified from Streptomyces clavuligerus.
J Biol Chem. 1989 Jun 15;264(17):10219-27.
8
Oxygen derepresses deacetoxycephalosporin C synthase and increases the conversion of penicillin N to cephamycin C in Streptomyces clavuligerus.在棒状链霉菌中，氧气可解除去乙酰氧基头孢菌素C合酶的抑制作用，并增加青霉素N向头霉素C的转化。
Enzyme Microb Technol. 1990 Jan;12(1):40-5. doi: 10.1016/0141-0229(90)90178-s.
9
A complete library of amino acid alterations at N304 in Streptomyces clavuligerus deacetoxycephalosporin C synthase elucidates the basis for enhanced penicillin analogue conversion.棒状链霉菌脱乙酰氧基头孢菌素C合酶中N304位点氨基酸改变的完整文库阐明了增强青霉素类似物转化的基础。
Appl Environ Microbiol. 2004 Jan;70(1):607-9. doi: 10.1128/AEM.70.1.607-609.2004.
10
Purification and characterization of a 2-oxoglutarate-linked ATP-independent deacetoxycephalosporin C synthase of Streptomyces lactamdurans.产黄青霉2-氧代戊二酸连接的不依赖ATP的脱乙酰氧基头孢菌素C合酶的纯化与特性分析
J Gen Microbiol. 1987 Nov;133(11):3165-74. doi: 10.1099/00221287-133-11-3165.

引用本文的文献

1
Engineering deacetoxycephalosporin C synthase as a catalyst for the bioconversion of penicillins.工程化脱乙酰氧基头孢菌素C合酶作为青霉素生物转化的催化剂。
J Ind Microbiol Biotechnol. 2017 May;44(4-5):705-710. doi: 10.1007/s10295-016-1857-0. Epub 2016 Nov 8.
2
Modified Deacetylcephalosporin C Synthase for the Biotransformation of Semisynthetic Cephalosporins.用于半合成头孢菌素生物转化的改良脱乙酰头孢菌素C合酶
Appl Environ Microbiol. 2016 Jun 13;82(13):3711-3720. doi: 10.1128/AEM.00174-16. Print 2016 Jul 1.
3
Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production.
用于头孢菌素生产的提高克拉维链霉菌去乙酰氧头孢菌素C合酶的定向进化和理性方法。
J Ind Microbiol Biotechnol. 2009 May;36(5):619-33. doi: 10.1007/s10295-009-0549-4. Epub 2009 Mar 7.
4
Nonribosomal peptide synthetases involved in the production of medically relevant natural products.参与医学相关天然产物合成的非核糖体肽合成酶。
Mol Pharm. 2008 Mar-Apr;5(2):191-211. doi: 10.1021/mp700137g. Epub 2008 Jan 25.
5
Molecular regulation of beta-lactam biosynthesis in filamentous fungi.丝状真菌中β-内酰胺生物合成的分子调控
Microbiol Mol Biol Rev. 1998 Sep;62(3):547-85. doi: 10.1128/MMBR.62.3.547-585.1998.
6
Characterization of Streptomyces sp. strain DRS-1 and its ampicillin transformation product.链霉菌属菌株DRS-1及其氨苄青霉素转化产物的特性分析
Folia Microbiol (Praha). 1997;42(4):333-6. doi: 10.1007/BF02816945.
7
Characterization of the cefF gene of Nocardia lactamdurans encoding a 3'-methylcephem hydroxylase different from the 7-cephem hydroxylase.
Appl Microbiol Biotechnol. 1996 Jan;44(5):605-9. doi: 10.1007/BF00172492.
8
Molecular analysis of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90.来自产内酰胺溶杆菌属YK90的头孢菌素生物合成相关基因簇的分子分析。
Appl Microbiol Biotechnol. 1996 Jan;44(5):589-96. doi: 10.1007/BF00172490.
9
Genes for beta-lactam antibiotic biosynthesis.β-内酰胺抗生素生物合成相关基因。
Antonie Van Leeuwenhoek. 1995;67(2):181-200. doi: 10.1007/BF00871213.
10
Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities.具有去乙酰氧基头孢菌素C合成酶和羟化酶活性的一种酶的纯化及初步表征
Biochem J. 1987 Aug 1;245(3):831-41. doi: 10.1042/bj2450831.