Baumgardner J E, Graves D J, Neufeld G R, Quinn J A
J Appl Physiol (1985). 1985 May;58(5):1536-45. doi: 10.1152/jappl.1985.58.5.1536.
The flux of He and O2 through intact adult human skin was measured at various inspired concentrations and skin temperatures. The skin surface was then stripped with cellophane tape to alter the diffusional conductance of the stratum corneum. He flux for stripped skin was used to estimate skin perfusion as a function of local temperature, and diffusional conductance for O2 was estimated from O2 flux and perfusion. The flux of He or O2 at constant skin temperature can be related to inspired concentration by a simple linear model. Increasing surface temperature in the range 33-43 degrees C produced a much larger increase in O2 flux than in He flux for intact skin. Skin stripping greatly increased skin O2 flux. Estimated skin conductance for O2 showed a more marked temperature dependence than estimated skin perfusion. The results suggest that raising skin temperature in the range 38-43 degrees C has only a modest effect on skin perfusion and that stratum corneum conductance may have a major role in the large increase of O2 flux with temperature.
在不同的吸入浓度和皮肤温度下，测量了氦气（He）和氧气（O₂）通过完整成人皮肤的通量。然后用玻璃纸胶带剥离皮肤表面，以改变角质层的扩散传导率。剥离皮肤的氦通量用于估计皮肤灌注作为局部温度的函数，氧气的扩散传导率则根据氧气通量和灌注来估计。在恒定皮肤温度下，氦气或氧气的通量可以通过一个简单的线性模型与吸入浓度相关联。对于完整皮肤，在33 - 43摄氏度范围内升高表面温度，氧气通量的增加比氦通量的增加要大得多。皮肤剥离极大地增加了皮肤氧气通量。估计的皮肤对氧气的传导率显示出比估计的皮肤灌注更明显的温度依赖性。结果表明，在38 - 43摄氏度范围内升高皮肤温度对皮肤灌注只有适度的影响，并且角质层传导率可能在氧气通量随温度大幅增加中起主要作用。
