野生型和修复缺陷型噬菌体T4菌株中当归素（异补骨脂素）或硫代吡咯宁（亚甲蓝）的光动力失活与诱变作用
Photodynamic inactivation and mutagenesis by angelicin (isopsoralen) or thiopyronin (methylene red) in wild-type and repair-deficient strains of bacteriophage T4.
作者信息
Drake J W
出版信息
J Bacteriol. 1985 Jun;162(3):1311-3. doi: 10.1128/jb.162.3.1311-1313.1985.
Abstract
Photodynamic inactivation of bacteriophage T4 particles, mediated by either angelicin or thiopyronin, is enhanced by defects in the T4 uvsW-uvsX-uvsY postreplication repair system but not by a defect in the denV pyrimidine-dimer-excision system. There was no evidence for functional interactions between the two repair systems. As observed previously with 8-methoxypsoralen, photodynamic mutagenesis with angelicin is abolished by defects in the uvsW-uvsX-uvsY system.
摘要
由白芷香豆素或硫代吡喃酮介导的噬菌体T4颗粒的光动力失活，会因T4 uvsW-uvsX-uvsY复制后修复系统的缺陷而增强，但不会因denV嘧啶二聚体切除系统的缺陷而增强。没有证据表明这两种修复系统之间存在功能相互作用。如之前用8-甲氧基补骨脂素所观察到的那样，uvsW-uvsX-uvsY系统的缺陷会消除白芷香豆素的光动力诱变作用。
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