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噬菌体T4中的伽马射线诱变

Gamma-ray mutagenesis in bacteriophage T4.

作者信息

Conkling M A, Grunau J A, Drake J W

出版信息

Genetics. 1976 Apr;82(4):565-75. doi: 10.1093/genetics/82.4.565.

DOI:10.1093/genetics/82.4.565
PMID:1269910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213480/
Abstract

137Cs-gamma irradiation of bacteriophage T4 induces large deletions plus a variety of types of point mutations. All mutations arise with single-hit kinetics, and all by a misrepair process. The estimated point mutation rate is 1.5 X 10(-9) per locus per rad.

摘要

用137Cs-γ射线照射噬菌体T4会诱发大片段缺失以及多种类型的点突变。所有突变均以单 hit 动力学产生，且均通过错配修复过程产生。估计的点突变率为每拉德每个基因座1.5×10⁻⁹。

相似文献

1
Gamma-ray mutagenesis in bacteriophage T4.噬菌体T4中的伽马射线诱变
Genetics. 1976 Apr;82(4):565-75. doi: 10.1093/genetics/82.4.565.
2
Misrepair mutagenesis in bacteriophage T4.噬菌体T4中的错配诱变
Genetics. 1974 Sep;78(1):81-9. doi: 10.1093/genetics/78.1.81.
3
gamma-Ray mutagenesis in bacteriophage T4 is not enhanced by oxygen.
Mutat Res. 1979 Jul;61(2):121-7. doi: 10.1016/0027-5107(79)90120-9.
4
Dependence of the UV sensitivity of phage T4 on the localization of conditionally lethal (amber) mutations in the genome.噬菌体T4紫外线敏感性对基因组中条件致死（琥珀型）突变定位的依赖性。
Sov Genet. 1973 Aug;7(2):234-8.
5
Repair of UV-induced mutations in phage T4.噬菌体T4中紫外线诱导突变的修复
Biochem Biophys Res Commun. 1971 Jun 18;43(6):1402-7. doi: 10.1016/s0006-291x(71)80030-x.
6
Study of genetic effects of high energy radiations with different ionizing capacities on extracellular phages.不同电离能力的高能辐射对细胞外噬菌体的遗传效应研究。
Mutat Res. 1975 Jul;29(1):1-20. doi: 10.1016/0027-5107(75)90017-2.
7
Tandem duplication of genes in phage T4.噬菌体T4中基因的串联重复。
Sov Genet. 1974 Sep 15;8(10):1266-8.
8
Effects of the Escherichia coli K12 recA56, uvrB and polA mutations on UV reactivation in bacteriophage T7.大肠杆菌K12的recA56、uvrB和polA突变对噬菌体T7紫外线复活作用的影响。
Mutat Res. 1975 May;28(2):305-8. doi: 10.1016/0027-5107(75)90108-6.
9
Gene function and strand breaks in DNA of gamma-irradiated T7 bacteriophages.γ射线辐照的T7噬菌体DNA中的基因功能与链断裂
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Sep;26(3):219-26. doi: 10.1080/09553007414551181.
10
Evidence for a third type of UV. repair in bacteriophage T4.噬菌体T4中第三种紫外线修复类型的证据。
Mutat Res. 1976 Apr;35(1):161-5. doi: 10.1016/0027-5107(76)90178-0.

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Methyl methanesulfonate mutagenesis in bacteriophage T4.噬菌体T4中的甲磺酸甲酯诱变
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3
Isolation and characterization of conditional alleles of bacteriophage T4 genes uvsX and uvsY.噬菌体T4基因uvsX和uvsY条件等位基因的分离与鉴定。
Genetics. 1984 Aug;107(4):505-23. doi: 10.1093/genetics/107.4.505.
4
Induction of c-mutations in extracellular phage lambda by gamma-rays.γ射线诱导细胞外噬菌体λ发生c基因突变。
Mol Gen Genet. 1982;188(1):111-4. doi: 10.1007/BF00333003.
5
Photodynamic inactivation and mutagenesis by angelicin (isopsoralen) or thiopyronin (methylene red) in wild-type and repair-deficient strains of bacteriophage T4.野生型和修复缺陷型噬菌体T4菌株中当归素（异补骨脂素）或硫代吡咯宁（亚甲蓝）的光动力失活与诱变作用
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6
Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells.碱基替换、移码突变和小片段缺失构成了哺乳动物细胞中电离辐射诱导的点突变。
Proc Natl Acad Sci U S A. 1988 Jan;85(1):185-8. doi: 10.1073/pnas.85.1.185.
7
Ionizing radiation-induced mutagenesis.电离辐射诱导的诱变作用。
Br J Cancer. 1988 Jan;57(1):6-18. doi: 10.1038/bjc.1988.2.
8
Changes in DNA base sequence induced by gamma-ray mutagenesis of lambda phage and prophage.由λ噬菌体和原噬菌体的γ射线诱变诱导的DNA碱基序列变化。
Genetics. 1988 Apr;118(4):551-60. doi: 10.1093/genetics/118.4.551.

本文引用的文献

1
Induction and reversion of c-mutations by irradiation of the extracellular k-phage of Serratia.通过照射粘质沙雷氏菌的细胞外k噬菌体诱导和逆转c突变
Nature. 1960 Apr 23;186:330-1. doi: 10.1038/186330b0.
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[THE MUTAGENIC ACTION OF IONIZING RADIATIONS ON EXTRACELLULAR BACTERIOPHAGES].[电离辐射对细胞外噬菌体的诱变作用]
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The induction of mutations by ionizing radiation in bacteriophage phi-X174 and in its purified DNA.电离辐射对噬菌体φ-X174及其纯化DNA的诱变作用。
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Induction of h-mutations in the extracellular phage T2 by gamma-irradiation.用γ射线辐照在细胞外噬菌体T2中诱导h基因突变。
Biochem Biophys Res Commun. 1964 Jul 27;16(5):455-9. doi: 10.1016/0006-291x(64)90375-4.
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Partial diploidy in phage T41.噬菌体T41中的部分二倍体。
Genetics. 1965 Sep;52(3):683-93. doi: 10.1093/genetics/52.3.683.
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Base-change mutagenesis and prophage induction in strains of Escherichia coli with different DNA repair capacities.不同DNA修复能力的大肠杆菌菌株中的碱基变化诱变和原噬菌体诱导
Genetics. 1970 Oct;66(2):187-217. doi: 10.1093/genetics/66.2.187.
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Mutagenesis in Escherichia coli. 3. Requirement for DNA synthesis in mutation by gamma rays of T4-phage complexed with Escherichia coli.
Genet Res. 1970 Apr;15(2):147-56.
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Reversion of cistron A amber mutants of bacteriophage phiX 174 by ionizing radiation.噬菌体φX 174的顺反子A琥珀突变体经电离辐射后的回复突变
Mutat Res. 1973 Jun;18(3):363-5. doi: 10.1016/0027-5107(73)90220-0.
9
The identification of prereplicative bacteriophage T4 proteins.复制前噬菌体T4蛋白的鉴定
J Biol Chem. 1973 Aug 10;248(15):5499-501.
10
Tandem duplications of the rII region of bacteriophage T4D.
Genetics. 1972 Jul;71(3):319-35. doi: 10.1093/genetics/71.3.319.