Avramović D, Sulović V, Lazarević B, Cvetković M, Milacić D
Jugosl Ginekol Opstet. 1979 Sep-Dec;19(5-6):307-11.
A double blind trial was performed in patients with Cesarean section in order to study the effect of Simeticon (Stuart Pharmaceutical Company, Pasadena, California) on the occurrence of subjective and objective signs of gas distress during the immediate postoperative period. The results obtained with Simeticon show a highly significant reduction of the analysed subjective complaints (nausea, vomiting, meteorism, discomfort in the stomach, abdominal pains) in relation to placebo. Peristaltic movements in patients treated with Simeticon appeared in the first two days in 100% of cases and only in 30% in the placebo group. Flatulence also appeared in all the patients receiving Simeticon, in contrast to only 20% in the placebo group. There was no difference in spontanous defecation between the groups. On the basis of the results obtained, and considering the non-toxicity of the drug, its chemical inertnees, good tolerance, and simple use, the authors consider simeticon very useful for the prevention and therapy of postoperative discomfort due to gas accumulation and gastro-intestinal distention after Cesarean section.
为研究西甲硅油(斯图尔特制药公司,加利福尼亚州帕萨迪纳)对剖宫产术后即刻气体不适主观和客观体征发生情况的影响,对剖宫产患者进行了一项双盲试验。与安慰剂相比,西甲硅油的研究结果显示,所分析的主观症状(恶心、呕吐、腹胀、胃部不适、腹痛)显著减少。接受西甲硅油治疗的患者蠕动在术后前两天100%出现,而安慰剂组仅为30%。接受西甲硅油治疗的所有患者均出现肠胃胀气,相比之下,安慰剂组仅为20%。两组间自主排便无差异。基于所获得的结果,并考虑到该药物的无毒性、化学惰性、良好耐受性和使用简便性,作者认为西甲硅油对预防和治疗剖宫产术后因气体积聚和胃肠道扩张引起的不适非常有用。