Krolewski A S, Warram J H, Cupples A, Gorman C K, Szabo A J, Christlieb A R
J Chronic Dis. 1985;38(4):319-26. doi: 10.1016/0021-9681(85)90078-5.
Prevalences of hypertension and orthostatic hypotension and their relationship to the microvascular complications of diabetes were assessed in 702 individuals aged 18-74 years, who had been selected as a representative sample of surviving patients with diabetes diagnosed at the Joslin Clinic between 1939 and 1965. In diabetes of short, long and very long duration, hypertension was 1.7, 1.9 and 2.1 times more frequent, respectively, than in the white U.S. population, regardless of gender. The excess frequency of hypertension in short duration diabetes suggests that some etiologic factor is shared by both conditions, while the magnification of the excess with increasing duration could be explained by an effect of diabetes on the kidney. Hypertension without accompanying proteinuria was not associated with retinopathy. Orthostatic hypotension was observed in 12% of the males and 13% of the females. The magnitude of the fall in systolic blood pressure was correlated with age, postprandial blood glucose, supine diastolic blood pressure, and the presence of retinopathy. Patients with proliferative retinopathy had the largest fall in systolic blood pressure.
对702名年龄在18至74岁之间的个体进行了评估，以确定高血压和直立性低血压的患病率及其与糖尿病微血管并发症的关系。这些个体是从1939年至1965年在乔斯林诊所被诊断为糖尿病的存活患者中选取的具有代表性的样本。在病程短、长和非常长的糖尿病患者中，无论性别如何，高血压的发生率分别比美国白人人群高1.7倍、1.9倍和2.1倍。短病程糖尿病中高血压的高发生率表明这两种情况存在一些共同的病因因素，而随着病程延长高血压发生率的增加可能是由于糖尿病对肾脏的影响所致。无蛋白尿伴随的高血压与视网膜病变无关。在12%的男性和13%的女性中观察到直立性低血压。收缩压下降的幅度与年龄、餐后血糖、仰卧位舒张压以及视网膜病变的存在相关。增殖性视网膜病变患者的收缩压下降幅度最大。
