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轻度地中海贫血婴儿的新冠后中性粒细胞减少症:病例报告

Post-COVID-19 Neutropenia in an Infant With Thalassemia Minor: Case Report.

作者信息

Elsherif Yasmine, Elsherif Omar, Karimi Mehran, Ibrahim Ismail A, Abukhadijah Hana J

机构信息

American Hospital Dubai (AHD) Dubai UAE.

Tbilisi State Medical University Tbilisi Georgia.

出版信息

Clin Case Rep. 2025 Feb 19;13(2):e9668. doi: 10.1002/ccr3.9668. eCollection 2025 Feb.

Abstract

This case of an 11-month-old female who developed severe neutropenia following COVID-19 infection underscores the need for heightened vigilance and monitoring of hematological parameters in infants post-COVID-19. The exact mechanism of COVID-19-induced neutropenia is not fully understood, but it may involve cytokine-induced suppression of hematopoiesis and bone marrow repression due to the inflammatory response. Given the potential for serious clinical implications, including increased susceptibility to infections, it is crucial to effectively identify and manage neutropenia in this vulnerable population. Further research is necessary to elucidate the underlying mechanisms and optimize treatment strategies for COVID-19-related hematological complications in infants.

摘要

一名11个月大的女性在感染新冠病毒后出现严重中性粒细胞减少症,该病例突显了对新冠病毒感染后婴儿的血液学参数提高警惕并进行监测的必要性。新冠病毒诱导中性粒细胞减少的确切机制尚未完全明确,但可能涉及细胞因子诱导的造血抑制以及炎症反应导致的骨髓抑制。鉴于其可能产生包括感染易感性增加在内的严重临床影响,在这一脆弱人群中有效识别和管理中性粒细胞减少症至关重要。有必要开展进一步研究以阐明潜在机制,并优化针对婴儿新冠病毒相关血液学并发症的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8347/11839831/ed93f2dab089/CCR3-13-e9668-g001.jpg

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