Cavalcante-Silva Luiz Henrique Agra, Carvalho Deyse Cristina Madruga, Lima Éssia de Almeida, Galvão José G F M, da Silva Juliane S de França, Sales-Neto José Marreiro de, Rodrigues-Mascarenhas Sandra
Laboratório de Imunobiotecnologia, Centro de Biotecnologia, Universidade Federal da Paraíba (UFPB), João Pessoa, Brazil.
Laboratório de Imunobiotecnologia, Centro de Biotecnologia, Universidade Federal da Paraíba (UFPB), João Pessoa, Brazil.
Int Immunopharmacol. 2021 Jan;90:107233. doi: 10.1016/j.intimp.2020.107233. Epub 2020 Nov 30.
The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyperinflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19 immunopathogenesis (e.g., dysfunctional IFN response and myeloid inflammation). In this regard, neutrophils have been highlighted as essential effector cells in the development of COVID-19. This review summarized the significant finds about neutrophils and its effector mechanisms (e.g., neutrophils enzymes and cytokines, neutrophil extracellular traps) in COVID-19 so far.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染引发了一种多系统炎症性疾病，即2019冠状病毒病（COVID-19），这是一种大流行性疾病。该疾病的特征是急性呼吸窘迫综合征、细胞因子驱动的过度炎症以及白细胞计数变化。固有免疫反应与COVID-19的免疫发病机制有关（例如，干扰素反应功能失调和髓系炎症）。在这方面，中性粒细胞已被视为COVID-19发展过程中的关键效应细胞。本综述总结了迄今为止关于COVID-19中中性粒细胞及其效应机制（例如，中性粒细胞酶和细胞因子、中性粒细胞胞外陷阱）的重要发现。
