Ding Mozhu, Schmidt-Mende Katharina, Modig Karin
Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Academic Primary Health Care Centre, Stockholm Region, Stockholm, Sweden.
JAMA Netw Open. 2025 Feb 3;8(2):e2461117. doi: 10.1001/jamanetworkopen.2024.61117.
A timely diagnosis is crucial in ensuring high-quality care for individuals with dementia. Comparing age and health status at the time of dementia diagnosis across population subgroups can provide insights into vulnerable groups that may experience delayed diagnosis and/or a poorer prognosis.
To examine how age and health at the time of dementia diagnosis vary across sociodemographic subgroups.
DESIGN, SETTING, AND PARTICIPANTS: A nationwide cross-sectional study of individuals with an incident dementia diagnosis from either specialist care or who were dispensed antidementia drugs, identified from the Swedish National Patient Register and the Prescribed Drug Register between January 2018 and December 2022.
Sociodemographic status at the time of dementia diagnosis was assessed through linkage with national registers and included education, place of birth, living arrangement, family status, and family disposable income.
Health status was assessed by calculating the number of dispensed medications during the year preceding dementia diagnosis, as well as the Charlson Comorbidity Index (CCI) and Hospital Frailty Risk Score (HFRS) using specialist diagnoses during the preceding 5 years.
Of the 107 707 individuals with a dementia diagnosis, 61 127 (56.8%) were women and the mean (SD) age at diagnosis was 82.0 (7.7) years. Individuals with lower education, living alone or in a care home, or without a close relative were a mean (SD) of 3.1 (7.3) years older when diagnosed with dementia compared with their counterparts. At the time of diagnosis, individuals who had lower than high school education had higher CCI (odds ratio [OR], 1.11; 95% CI, 1.07-1.15) and more medications (OR, 1.38; 95% CI, 1.33-1.44) compared with those with university education. Age and health status at dementia diagnosis did not differ significantly by place of birth or income.
This nationwide register-based study indicated that clinical diagnosis of dementia may be significantly delayed among individuals with low education, those living alone or in a care home, or those without a close relative. These groups also had poorer health at the time of dementia diagnosis, which may impact their prognosis negatively. Future efforts should focus on improving health services to better address the diagnostic and care needs of these vulnerable subgroups.
及时诊断对于确保为痴呆症患者提供高质量护理至关重要。比较不同人群亚组在痴呆症诊断时的年龄和健康状况,可以深入了解可能经历诊断延迟和/或预后较差的弱势群体。
研究痴呆症诊断时的年龄和健康状况在社会人口学亚组中的差异。
设计、背景和参与者:一项全国性横断面研究,研究对象为2018年1月至2022年12月期间从瑞典国家患者登记册和处方药登记册中确定的新发痴呆症诊断患者,这些患者来自专科护理或正在使用抗痴呆药物。
通过与国家登记册关联评估痴呆症诊断时的社会人口学状况,包括教育程度、出生地、居住安排、家庭状况和家庭可支配收入。
通过计算痴呆症诊断前一年的配药数量,以及使用前5年的专科诊断计算查尔森合并症指数(CCI)和医院虚弱风险评分(HFRS)来评估健康状况。
在107707例痴呆症诊断患者中,61127例(56.8%)为女性,诊断时的平均(标准差)年龄为82.0(7.7)岁。与其他人群相比,受教育程度较低、独居或住在养老院、或没有近亲的人在被诊断为痴呆症时平均(标准差)年龄大3.1(7.3)岁。诊断时,与大学学历者相比,高中以下学历者的CCI更高(优势比[OR],1.11;95%置信区间,1.07-1.15),用药更多(OR,1.38;95%置信区间,1.33-1.44)。痴呆症诊断时的年龄和健康状况在出生地或收入方面没有显著差异。
这项基于全国登记册的研究表明,受教育程度低、独居或住在养老院、或没有近亲的人痴呆症的临床诊断可能会显著延迟。这些人群在痴呆症诊断时健康状况也较差,这可能会对其预后产生负面影响。未来的努力应集中在改善卫生服务,以更好地满足这些弱势群体的诊断和护理需求。