34βE12是角蛋白源性皮肤淀粉样变最可靠的标志物：一项比较研究。

34βE12 is the Most Reliable Marker for Keratin-Derived Cutaneous Amyloid: A Comparative Study.

作者信息

Daruish Maged, Al-Sharbatee Ghada, D'Arrigo Corrado, Taibjee Saleem

机构信息

Department of Cellular Pathology, Dorset County Hospital NHS Foundation Trust, Dorchester, United Kingdom.

Poundbury Cancer Institute, Dorchester, United Kingdom ; and.

出版信息

Am J Dermatopathol. 2025 Jun 1;47(6):439-441. doi: 10.1097/DAD.0000000000002942. Epub 2025 Feb 19.

DOI:10.1097/DAD.0000000000002942

PMID:39983073

Abstract

Congo red (CR) remains the most commonly used stain by pathologists to detect amyloid deposition. CR, however, has limitations including variable sensitivity with potential of false negative results. We investigated the staining intensity of CR in comparison to commercially available cytokeratin immunohistochemical markers in a series of primary cutaneous amyloidosis originating from keratin filaments.

摘要

刚果红（CR）仍然是病理学家检测淀粉样蛋白沉积最常用的染色剂。然而，CR存在局限性，包括敏感性不一，可能出现假阴性结果。我们在一系列源自角蛋白丝的原发性皮肤淀粉样变性中，将CR的染色强度与市售细胞角蛋白免疫组化标志物进行了比较。