Perić Leon, Drenjančević Ines, Jukić Ivana, Boris Alina, Šušnjara Petar, Kolobarić Nikolina, Mihaljević Zrinka, Kralik Zlata, Kralik Gordana, Košević Manuela, Galović Olivera, Stupin Ana
Department of Ophthalmology, University Hospital Center Osijek, Osijek, Croatia.
Scientific Centre of Excellence for Personalized Health Care, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Appl Physiol Nutr Metab. 2025 Jan 1;50:1-11. doi: 10.1139/apnm-2024-0458.
This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes. Both forearm skin micro- and macrovascular endothelium-independent vasodilation were increased, and diastolic and mean arterial blood pressure (BP) were decreased in Carnosine group ( = 19) following the 3-week dietary protocol. Microvascular endothelium-dependent response (post-occlusion reactive hyperemia) was increased in the Carnosine group and significantly associated with decreased mean arterial BP level. Following dietary protocol, Controls ( = 16) had substantially higher urate (but still normal) levels than the Carnosine group. Carnosine supplementation in the form of functional food enhances endothelium-dependent and vascular smooth muscle-dependent vasodilation in peripheral micro- and microcirculation. Carnosine's effect on vascular endothelium could be attributed to its BP-lowering effect. Results suggest that carnosine has the potential to resist hyperuricemia in healthy individuals. ClinicalTrials.gov (NCT05723939).
这项随机干预研究旨在调查食用富含肌肽的鸡肉对35名健康的男性竞技运动员全身内皮依赖性和非内皮依赖性微血管及大血管反应性的影响。在为期3周的饮食方案后，肌肽组（n = 19）的前臂皮肤微血管和大血管非内皮依赖性血管舒张均增加，舒张压和平均动脉血压（BP）降低。肌肽组的微血管内皮依赖性反应（闭塞后反应性充血）增加，且与平均动脉血压水平降低显著相关。饮食方案实施后，对照组（n = 16）的尿酸水平比肌肽组高得多（但仍正常）。以功能性食品形式补充肌肽可增强外周微循环和微循环中内皮依赖性和血管平滑肌依赖性血管舒张。肌肽对血管内皮的作用可能归因于其降压作用。结果表明，肌肽有潜力在健康个体中抵抗高尿酸血症。ClinicalTrials.gov（NCT05723939）。
