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短期高热量饮食对男性大脑胰岛素作用具有长期影响。

A short-term, high-caloric diet has prolonged effects on brain insulin action in men.

作者信息

Kullmann Stephanie, Wagner Lore, Hauffe Robert, Kühnel Anne, Sandforth Leontine, Veit Ralf, Dannecker Corinna, Machann Jürgen, Fritsche Andreas, Stefan Nobert, Preissl Hubert, Kroemer Nils B, Heni Martin, Kleinridders André, Birkenfeld Andreas L

机构信息

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.

German Center for Diabetes Research (DZD), Neuherberg, Germany.

出版信息

Nat Metab. 2025 Mar;7(3):469-477. doi: 10.1038/s42255-025-01226-9. Epub 2025 Feb 21.

DOI:10.1038/s42255-025-01226-9
PMID:39984682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11946887/
Abstract

Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.

摘要

大脑胰岛素敏感性与长期体重增加和不健康的体脂分布有关。我们在此表明，在体重正常的男性中，短期内过量食用富含卡路里的甜食和脂肪类食物会引发肝脏脂肪堆积，并导致大脑胰岛素作用紊乱，且这种紊乱在食物摄入期结束后仍持续存在。因此，在体重增加之前，大脑对胰岛素的反应就能适应饮食的短期变化，这可能会促使肥胖及相关疾病的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/8f90675d4084/42255_2025_1226_Fig5_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/82d1cc5b7ba6/42255_2025_1226_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/cffc03f2081a/42255_2025_1226_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/aa7f1fe8b6f2/42255_2025_1226_Fig3_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/6d33dc1288fb/42255_2025_1226_Fig4_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/8f90675d4084/42255_2025_1226_Fig5_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/82d1cc5b7ba6/42255_2025_1226_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/cffc03f2081a/42255_2025_1226_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/aa7f1fe8b6f2/42255_2025_1226_Fig3_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/6d33dc1288fb/42255_2025_1226_Fig4_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5108/11946887/8f90675d4084/42255_2025_1226_Fig5_ESM.jpg

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本文引用的文献

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Nat Metab. 2023 Sep;5(9):1475-1482. doi: 10.1038/s42255-023-00869-w. Epub 2023 Sep 21.
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Impact of insulin and insulin resistance on brain dopamine signalling and reward processing - An underexplored mechanism in the pathophysiology of depression?胰岛素及胰岛素抵抗对脑多巴胺信号传导和奖赏处理的影响——抑郁症病理生理学中一个未被充分探索的机制？
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Brain insulin responsiveness is linked to age and peripheral insulin sensitivity.
大脑胰岛素反应性与年龄和外周胰岛素敏感性有关。
Diabetes Obes Metab. 2023 Aug;25(8):2171-2180. doi: 10.1111/dom.15094. Epub 2023 May 4.
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Habitual daily intake of a sweet and fatty snack modulates reward processing in humans.习惯性地每天摄入甜食和高脂肪零食会调节人类的奖励处理过程。
Cell Metab. 2023 Apr 4;35(4):571-584.e6. doi: 10.1016/j.cmet.2023.02.015. Epub 2023 Mar 22.
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Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese.运动可恢复超重和肥胖的久坐成年人的大脑胰岛素敏感性。
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Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity.胰岛素信号在成神经细胞中调节下丘脑胰岛素摄取和 AgRP 神经元活性。
Nat Metab. 2021 Dec;3(12):1662-1679. doi: 10.1038/s42255-021-00499-0. Epub 2021 Dec 20.
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Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial.恩格列净可改善糖尿病前期患者下丘脑的胰岛素敏感性：一项随机、双盲、安慰剂对照、2 期临床试验。
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White matter integrity differences in obesity: A meta-analysis of diffusion tensor imaging studies.肥胖症患者的脑白质完整性差异：一项弥散张量成像研究的荟萃分析。
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