Research Center of the Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, 2725 chemin Sainte-Foy, Québec, Québec, G1V 4G5, Canada; School of Nutrition, Université Laval, 2325 rue de l'Université, Québec, Québec, G1V 0A6, Canada.
Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, Québec, H3A 2B4, Canada.
Neurosci Biobehav Rev. 2021 Oct;129:133-141. doi: 10.1016/j.neubiorev.2021.07.020. Epub 2021 Jul 17.
Some Diffusion Tensor Imaging studies have shown a loss of white matter (WM) integrity linked to impaired cognitive function in obese individuals. However, inconsistent WM integrity changes have been reported. We aimed to identify which WM tracts show consistent changes with obesity. We conducted a systematic search to find studies examining the association between obesity-related measures and Fractional Anisotropy (FA) or Mean Diffusivity. We performed a meta-analysis with FA datasets using Anisotropic Effect Size-Signed Differential Mapping software. The meta-analysis showed that increased obesity measurements were related to reduced FA in the genu of the corpus callosum. We validated our findings using an independent sample from the Human Connectome Project dataset, which supports lower FA in this region in individuals with obesity compared to those with normal weight (p = 0.028). Our findings provide evidence that obesity is associated with reduced WM integrity in the genu of the corpus callosum, a tract linking frontal areas involved in executive function. Future studies are needed on the mechanisms linking obesity with loss of WM integrity.
一些弥散张量成像研究表明，肥胖个体的认知功能受损与白质（WM）完整性的丧失有关。然而，也有报道称 WM 完整性的变化不一致。我们旨在确定哪些 WM 束与肥胖存在一致的变化。我们进行了系统检索，以找到研究肥胖相关指标与分数各向异性（FA）或平均扩散率之间关系的研究。我们使用各向异性效应大小-符号差异映射软件对 FA 数据集进行了荟萃分析。荟萃分析表明，肥胖测量值的增加与胼胝体膝部 FA 的降低有关。我们使用来自人类连接组计划数据集的独立样本验证了我们的发现，这支持了肥胖个体在该区域的 FA 低于体重正常个体（p = 0.028）。我们的研究结果表明，肥胖与胼胝体膝部 WM 完整性的降低有关，胼胝体膝部是一个连接参与执行功能的额叶区域的束。需要进一步研究肥胖与 WM 完整性丧失之间的机制。
