来自乌药（Lindera aggregata (Sims) Kosterm.）根中的具有神经保护作用的乌药烷倍半萜类化合物
Neuroprotective lindenane sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm.
作者信息
Ma Lie-Feng, Luo Shan-Rong, Liu Qian-Qing, Tang Rui-Si, Chen Ning-Yu, Luo Di, Guo Lu, Li Jia, Wu Rui, Zhan Zha-Jun
机构信息
Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, PR China.
School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, PR China.
出版信息
Phytochemistry. 2025 Jul;235:114452. doi: 10.1016/j.phytochem.2025.114452. Epub 2025 Feb 20.
Eleven previously undescribed lindenane sesquiterpenoids, lindaggrols A-K (1-11), were isolated from the roots of Lindera aggregata (Sims) Kosterm, together with five known ones. Their structures were elucidated by HR-ESI-MS, NMR, and single-crystal X-ray diffraction analyses. Lindaggrol A (1) is an undescribed rearranged dinor-lindenane with an unprecedented 3/5/5 tricyclic scaffold. All isolated compounds were assayed for their neuroprotective effects against erastin-induced ferroptosis in HT-22 cells. Among them, 3, 12 and 14 exhibited significant neuroprotective activities with EC values ranging from 1.4 to 8.7 μM.
从聚合山胡椒（Lindera aggregata (Sims) Kosterm）的根部分离出11个之前未被描述的椴烷倍半萜类化合物，即山胡椒醇A - K（1 - 11），以及5个已知化合物。通过高分辨电喷雾电离质谱（HR-ESI-MS）、核磁共振（NMR）和单晶X射线衍射分析确定了它们的结构。山胡椒醇A（1）是一种未被描述的重排双降椴烷，具有前所未有的3/5/5三环骨架。对所有分离得到的化合物进行了检测，考察其对HT-22细胞中依托泊苷诱导的铁死亡的神经保护作用。其中，3、12和14表现出显著的神经保护活性，其半数有效浓度（EC）值在1.4至8.7 μM之间。
Zotero 插件