Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, PR China.
School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, PR China.
Phytochemistry. 2024 Aug;224:114150. doi: 10.1016/j.phytochem.2024.114150. Epub 2024 May 18.
In our search for neuroprotective agents, six previously undescribed highly oxidized guaiane sesquiterpenes, linderaggrols A-F (1-6), together with three known sesquiterpenes, were isolated from the roots of Lindera aggregata (Sims) Kosterm. Their structures including absolute configurations were established by a combination of NMR spectroscopic techniques and single crystal X-ray diffraction experiments. Compounds 1-6 represented the first instances of guaiane 12(8),15(6)-dilactones. Additionally, compound 6 possessed a rare 1,8-O-bridge. Neuroprotective effects against erastin-induced ferroptosis on HT-22 cells showed that some compounds demonstrated neuroprotective effects at 20.0 μM.
在寻找神经保护剂的过程中，我们从山鸡椒（Lindera aggregata (Sims) Kosterm.）的根部分离得到了六种以前未被描述的高度氧化的愈创木烷倍半萜，即 linderaggrols A-F（1-6），以及三种已知的倍半萜。通过 NMR 波谱技术和单晶 X 射线衍射实验的组合，确定了它们的结构，包括绝对构型。化合物 1-6 代表了guaiane 12(8),15(6)-二内酯的首次实例。此外，化合物 6 具有罕见的 1,8-O-桥。对 HT-22 细胞中 erastin 诱导的铁死亡的神经保护作用表明，一些化合物在 20.0 μM 时表现出神经保护作用。
