Zhang Hong, Ma Jun, Wang Jing, Zhu Wenting, Liu Xuebing
Wuhan Mental Health Center, Wuhan, China
Wuhan Mental Health Center, Wuhan, China.
BMJ Open. 2025 Feb 22;15(2):e087640. doi: 10.1136/bmjopen-2024-087640.
This study aimed to investigate the incidence of overweight in patients with major depressive disorder (MDD) comorbid anxiety during the acute phase and to explore associated factors.
Cross-sectional study.
Wuhan Mental Health Center, China, from July 2017 to August 2022.
737 hospitalised patients diagnosed with MDD in the acute phase with comorbid anxiety symptoms.
Incidence and clinical correlations of overweight (body mass index (BMI) ≥ 24).
Among the study population, 55.63% were classified as overweight. Binary logistic regression analysis revealed that being married (B=0.28, p value=0.018, OR=1.10), thyroid-stimulating hormone (TSH) levels (B=0.10, p value=0.001, OR=1.10) and low-density lipoprotein cholesterol (LDL-C) levels (B=1.61, p value=0.045, OR=1.18) were significant positive predictors of overweight. Additionally, multiple linear regression indicated that TSH levels (B=0.16, t=3.17, p value=0.002) were positively associated with higher BMI values.
Over half of the hospitalised MDD patients with comorbid anxiety are overweight. Thyroid function emerges as a crucial clinical factor for overweight in this population. Targeted interventions focusing on thyroid function may be a promising approach for managing overweight in these patients.
本研究旨在调查伴有焦虑症的重度抑郁症（MDD）患者急性期超重的发生率，并探索相关因素。
横断面研究。
中国武汉精神卫生中心，时间为2017年7月至2022年8月。
737名急性期诊断为MDD且伴有焦虑症状的住院患者。
超重（体重指数（BMI）≥24）的发生率及临床相关性。
在研究人群中，55.63%被归类为超重。二元逻辑回归分析显示，已婚（B = 0.28，p值 = 0.018，OR = 1.10）、促甲状腺激素（TSH）水平（B = 0.10，p值 = 0.001，OR = 1.10）和低密度脂蛋白胆固醇（LDL-C）水平（B = 1.61，p值 = 0.045，OR = 1.18）是超重的显著正预测因子。此外，多元线性回归表明TSH水平（B = 0.16，t = 3.17，p值 = 0.002）与较高的BMI值呈正相关。
超过一半伴有焦虑症的MDD住院患者超重。甲状腺功能成为该人群超重的关键临床因素。针对甲状腺功能的靶向干预可能是管理这些患者超重问题的一种有前景的方法。
