Pentel P, Fletcher D, Jentzen J
J Forensic Sci. 1985 Apr;30(2):556-62.
Selenium is used widely in industry and as a dietary supplement. Reports of acute selenium toxicity are infrequent, however, and the relationship of toxicity to selenium concentrations in blood and tissues has not been established. We describe a patient who died eight days after ingesting selenious acid in the form of gun blueing. The patient's clinical course demonstrated many of the features of inorganic selenium toxicity described in animals; hypotension as a result of both vasodilation and decreased cardiac output, adult respiratory distress syndrome, severe myopathy which contributed to respiratory failure, and a garlicky odor to the breath. Four days after ingestion the serum selenium concentration was twenty times normal and urinary excretion seventy times normal. Postmortem tissue selenium concentrations were up to 40 times normal.
硒在工业中广泛使用，并作为膳食补充剂。然而，急性硒中毒的报告并不常见，而且中毒与血液和组织中硒浓度的关系尚未明确。我们描述了一名患者，其在摄入枪用发蓝剂形式的亚硒酸八天后死亡。该患者的临床病程表现出许多动物无机硒中毒的特征；因血管扩张和心输出量减少导致的低血压、成人呼吸窘迫综合征、导致呼吸衰竭的严重肌病以及呼吸有蒜臭味。摄入后四天，血清硒浓度是正常水平的20倍，尿排泄量是正常水平的70倍。尸检时组织硒浓度高达正常水平的40倍。
