Tariq Arafat Hassan, Ali Huzaifa
CMH Institute of Medical Sciences, Multan, Punjab, Pakistan.
Pediatr Cardiol. 2025 Feb 22. doi: 10.1007/s00246-025-03804-w.
In response to the article "Evaluation of Cardiac Function in Children Undergoing Liver Transplantation" by Bansal et al., I admire the authors for their valuable insights in evaluating biventricular heart function in pediatric patients undergoing Liver Transplantation. However, I bring up several key concerns regarding study's methodology. The diversity of the pediatric cirrhosis population is limited by the study's small sample size, which consists of only 35 children patients. Advanced diagnostic techniques including tissue Doppler echocardiography and cardiovascular magnetic resonance (CMR), which are valuable for diagnosis of heart diseases, are not included in the study. The lack of a reference group of patients without cirrhosis makes it more difficult to confirm whether the cardiac dysfunction shown is unique to cirrhosis or indicates other chronic disease. Additionally, the study does not provides information regarding the outcomes following liver transplantation especially reversibility of cardaic abnormalities.
针对班萨尔等人发表的《肝移植儿童心脏功能评估》一文，我赞赏作者在评估接受肝移植的儿科患者双心室心脏功能方面的宝贵见解。然而，我对该研究的方法提出几个关键问题。该研究样本量小，仅包括35名儿童患者，这限制了儿科肝硬化人群的多样性。该研究未纳入对心脏病诊断有价值的先进诊断技术，包括组织多普勒超声心动图和心血管磁共振（CMR）。缺乏无肝硬化患者的参照组使得更难确定所显示的心脏功能障碍是肝硬化特有的，还是表明存在其他慢性疾病。此外，该研究未提供肝移植后结果的信息，尤其是心脏异常的可逆性。
