Corsini Christian, Pozzi Edoardo, Belladelli Federico, Bertini Alessandro, Negri Fausto, Raffo Massimiliano, Boeri Luca, Ventimiglia Eugenio, Candela Luigi, D'Arma Alessia, Montorsi Francesco, Salonia Andrea
Division of Experimental Oncology/Unit of Urology; URI; IRCCS Ospedale San Raffaele, Milan, Italy.
University Vita-Salute San Raffaele, Milan, Italy.
Int J Impot Res. 2025 Feb 22. doi: 10.1038/s41443-025-01029-2.
We aimed to depict the age-specific distribution of total Testosterone (tT) levels among young men presenting to a single academic centre with uro-andrological complaints. Overall, tT levels from 2593 men aged 20-44 years were analyzed. Men were grouped into 'infertile men' and 'men with sexual dysfunction (SD)' according to their primary complaints. Data was also collected from 71 same-ethnicity age-comparable fertile controls. Linear regression fitted the relationship between tT and increasing age. Distribution of tT was determined for each 5-year age-group, both for the overall population and the subgroups. tT quantiles were reported for each sample sub-group and age-group. Of 2664 men, 1913 (71.81%) were classified as infertile, 680 (25.52%) with SD and 71 as fertile men (2.67%), respectively. tT levels depicted a reduction of 0.14 nmol/L per year between 20 and 44 years of age (p < 0.001) within the overall study population. Significant reduction was also observed for the population stratified by urological complaints (all p < 0.05). This is the first study to describe tT levels as a function of baseline clinical status in a large same-ethnicity cohort of young men, uniformly assessed using a standardized laboratory method.
我们旨在描绘前往单一学术中心就诊、有泌尿和男科问题主诉的年轻男性中总睾酮（tT）水平的年龄特异性分布情况。总体而言，对2593名年龄在20 - 44岁男性的tT水平进行了分析。根据主要主诉，将男性分为“不育男性”和“性功能障碍（SD）男性”。还从71名年龄相仿、同种族的可育对照者中收集了数据。通过线性回归拟合tT与年龄增长之间的关系。确定了总体人群和各亚组中每5岁年龄组的tT分布情况。报告了每个样本亚组和年龄组的tT分位数。在2664名男性中，分别有1913名（71.81%）被归类为不育，680名（25.52%）有性功能障碍，71名（2.67%）为可育男性。在整个研究人群中，20至44岁之间tT水平每年下降0.14 nmol/L（p < 0.001）。按泌尿问题分层的人群中也观察到显著下降（所有p < 0.05）。这是第一项在大量同种族年轻男性队列中，使用标准化实验室方法统一评估，将tT水平描述为基线临床状态函数的研究。
