Cawthraw Shaun, Wales Andrew, Guzinski Jaromir, Trew Jahcub, Ring Isaac, Huby Tom, Hussaini Arslan, Petrovska Liljana, Martelli Francesca
Department of Bacteriology, Animal and Plant Health Agency (APHA-Weybridge), New Haw, Surrey KT15 3NB, United Kingdom.
Department of Comparative Biomedical Sciences, School of Veterinary Medicine, University of Surrey, Guildford, Surrey GU2 7AL, United Kingdom.
J Appl Microbiol. 2025 Mar 3;136(3). doi: 10.1093/jambio/lxaf040.
To describe the analysis, epidemiology, and control of six contemporaneous and linked outbreaks of Salmonella enterica subsp. enterica serovar Infantis on British broiler farms. Salmonella Infantis is a potentially multidrug-resistant foodborne zoonosis and can persistently colonize poultry flocks and farms.
Routine monitoring initially identified the organism, which was tracked to six farms associated with a single company. Extensive, repeat sampling identified widespread and, in some cases, persistent contamination. Salmonella Infantis was also isolated from three associated processing factories and catching crew equipment, but not from associated hatcheries and feed mills. Whole genome sequencing and resistance phenotyping revealed one strain was present in the processing plants and on five farms. However, on one of those farms, several highly genetically distinct strains were also detected, including one also found in one of the processing plants. The sixth farm had a strain that was genetically unrelated to strains collected from the other premises and which exhibited an extended spectrum beta-lactamase phenotype. Cleaning and disinfection were enhanced, and the organism was eventually cleared from all farms.
There were multiple incursions of varied strains, with a possible link to processing factories. Elimination of S. Infantis from premises can be challenging but achievable.
描述英国肉鸡养殖场同时发生的6起相互关联的肠炎沙门氏菌亚种婴儿亚种疫情的分析、流行病学情况及防控措施。婴儿亚种沙门氏菌是一种具有潜在多重耐药性的食源性人畜共患病原体，可在家禽群和养殖场中持续定植。
常规监测最初发现了该病原体，并追踪到与一家公司相关的6个养殖场。广泛的重复采样发现存在广泛污染，在某些情况下污染持续存在。婴儿亚种沙门氏菌还从3个相关的加工厂和抓鸡人员的设备中分离出来，但未从相关的孵化场和饲料厂中分离出来。全基因组测序和耐药表型分析显示，加工厂和5个养殖场中存在一个菌株。然而，在其中一个养殖场中，还检测到了几种遗传差异很大的菌株，其中一种也在其中一个加工厂中发现。第六个养殖场的菌株与从其他场所采集的菌株在基因上不相关，且表现出超广谱β-内酰胺酶表型。加强了清洁和消毒措施，最终该病原体从所有养殖场中清除。
有多种不同菌株的入侵，可能与加工厂有关。从场所中消除婴儿亚种沙门氏菌具有挑战性，但可以实现。
