Yang Xuefeng, Fedumenti Fernando Tavares, Niethard Niels, Hallschmid Manfred, Born Jan, Rauss Karsten
Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany.
Graduate School of Neural and Behavioural Science, International Max Planck Research School, Tübingen, Germany.
Sleep. 2025 Jun 13;48(6). doi: 10.1093/sleep/zsaf042.
Studies in rats indicate that oscillatory signatures of memory processing during sleep, specifically hippocampal sharp wave-ripples, also regulate peripheral glucose concentration. Here, we examined whether there is a similar link between such signatures of memory processing and glucose regulation during sleep in healthy humans. We obtained polysomnographic recordings and continuous recordings of peripheral interstitial glucose levels (1 sample/minute) from 10 participants (5 females) during two consecutive nights. Temporal relationships between electroencephalography (EEG) events of interest and glucose levels were examined using cross-correlation functions and peri-event time histograms. Confirming the findings in rats, we found that sleep spindles, a core signature of sleep-dependent memory processing, were followed within 1-6 minutes by a robust decrease in glucose concentrations. By contrast, slow oscillation events hallmarking slow wave sleep were followed, with a lag of 5-11 minutes, by an increase in glucose levels. Transitions into rapid eye movement sleep were followed by a glucose decrease after 10-14 minutes, whereas awakenings and microarousals were linked to immediate glucose increases. These temporal relationships indicate a sleep-specific regulation of peripheral glucose concentrations that is linked to both signatures of sleep-dependent memory processing as well as the macro-architecture of sleep. They possibly reflect noradrenergic regulation of sympathetic activity via the brainstem locus coeruleus and may be of relevance in clinical conditions with concurrent disturbances of sleep and glucose regulation.
对大鼠的研究表明，睡眠期间记忆处理的振荡特征，特别是海马体尖波涟漪，也会调节外周葡萄糖浓度。在此，我们研究了在健康人类睡眠期间，这种记忆处理特征与葡萄糖调节之间是否存在类似的联系。我们在连续两个晚上，从10名参与者（5名女性）那里获取了多导睡眠图记录以及外周组织间液葡萄糖水平的连续记录（每分钟1个样本）。使用互相关函数和事件周围时间直方图，研究了感兴趣的脑电图（EEG）事件与葡萄糖水平之间的时间关系。与对大鼠的研究结果一致，我们发现，睡眠纺锤波作为睡眠依赖性记忆处理的核心特征，在1至6分钟内会伴随着葡萄糖浓度的显著下降。相比之下，标志着慢波睡眠的慢振荡事件之后，会在5至11分钟的延迟后出现葡萄糖水平的上升。进入快速眼动睡眠后，10至14分钟后会出现葡萄糖下降，而觉醒和微觉醒则与葡萄糖立即升高有关。这些时间关系表明外周葡萄糖浓度存在睡眠特异性调节，这与睡眠依赖性记忆处理的特征以及睡眠的宏观结构都有关联。它们可能反映了通过脑干蓝斑对交感神经活动的去甲肾上腺素能调节，并且可能在同时存在睡眠和葡萄糖调节紊乱的临床病症中具有相关性。
