Carbonell Felix, McNicoll Carolann, Zijdenbos Alex P, Bedell Barry J
Biospective Inc., Montreal, Quebec, Canada.
Alzheimers Dement. 2025 Feb;21(2):e14625. doi: 10.1002/alz.14625.
Positron emission tomography (PET) imaging studies have shown that amyloid beta (Aβ) is significantly correlated with glucose metabolism in mild cognitive impairment independently of the apolipoprotein E (APOE) ε4 genotype.
We used a singular value decomposition (SVD) approach to pairwise cross-correlation among tau, Aβ, and fluorodeoxyglucose PET images. The resulting SVD-based tau and Aβ scores as well as the APOE ε4 genotype, were entered as predictors in a voxelwise general linear model for statistical assessment of their effect on FDG.
We found cortical regions where a reduced glucose metabolism was maximally correlated with distributed patterns of tau, accounting for the effect of Aβ and APOE ε4 genotype.
By highlighting the more significant role of tau, rather than Aβ, in the reduction of glucose metabolism, our results provide a better understanding of their combined effect in the development and progression of Alzheimer's disease.
This study uses a data-driven singular value decomposition approach to the cross-correlation matrix between tau and fluorodeoxyglucose (FDG) images, as well as between FDG and amyloid beta (Aβ) positron emission tomography (PET) images. From a population of mild cognitive impairment subjects, we found that spatially distributed scores of tau PET are associated with an even stronger reduction of glucose metabolism, independent of the apolipoprotein E ε4 genotype and confounded by Aβ. By highlighting the more significant role of tau, rather than Aβ, on the reduction of glucose metabolism, our results provide a better understanding of their combined effects in the development of Alzheimer's disease.
正电子发射断层扫描（PET）成像研究表明，在轻度认知障碍中，淀粉样β蛋白（Aβ）与葡萄糖代谢显著相关，且与载脂蛋白E（APOE）ε4基因型无关。
我们使用奇异值分解（SVD）方法对tau蛋白、Aβ和氟脱氧葡萄糖PET图像进行成对互相关分析。将基于SVD得出的tau蛋白和Aβ评分以及APOE ε4基因型作为预测因子，纳入体素水平的一般线性模型，以统计评估它们对氟脱氧葡萄糖（FDG）的影响。
我们发现了一些皮质区域，其中葡萄糖代谢降低与tau蛋白的分布模式具有最大相关性，且该相关性考虑了Aβ和APOE ε4基因型的影响。
通过强调tau蛋白而非Aβ在葡萄糖代谢降低中的更重要作用，我们的结果有助于更好地理解它们在阿尔茨海默病发展和进展中的联合作用。
本研究采用数据驱动的奇异值分解方法，对tau蛋白与氟脱氧葡萄糖（FDG）图像之间以及FDG与淀粉样β蛋白（Aβ）正电子发射断层扫描（PET）图像之间的互相关矩阵进行分析。在轻度认知障碍受试者群体中，我们发现tau蛋白PET的空间分布评分与葡萄糖代谢的更强降低相关，这与载脂蛋白E ε4基因型无关且不受Aβ的混淆影响。通过强调tau蛋白而非Aβ在葡萄糖代谢降低中的更重要作用，我们的结果有助于更好地理解它们在阿尔茨海默病发展中的联合作用。
