Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
German Center for Neurodegenerative Diseases, Munich, Germany.
Alzheimers Res Ther. 2020 Oct 19;12(1):133. doi: 10.1186/s13195-020-00702-6.
FDG-PET hypermetabolism can be observed in mild cognitive impairment (MCI), but the link to primary pathologies of Alzheimer's diseases (AD) including amyloid and tau is unclear.
Using voxel-based regression, we assessed local interactions between amyloid- and tau-PET on spatially matched FDG-PET in 72 MCI patients. Control groups included cerebrospinal fluid biomarker characterized cognitively normal (CN, n = 70) and AD dementia subjects (n = 95).
In MCI, significant amyloid-PET by tau-PET interactions were found in frontal, lateral temporal, and posterior parietal regions, where higher local tau-PET was associated with higher spatially corresponding FDG-PET at low levels of local amyloid-PET. FDG-PET in brain regions with a significant local amyloid- by tau-PET interaction was higher compared to that in CN and AD dementia and associated with lower episodic memory.
Higher tau-PET in the presence of low amyloid-PET is associated with abnormally increased glucose metabolism that is accompanied by episodic memory impairment.
轻度认知障碍（MCI）中可观察到 FDG-PET 代谢亢进，但与阿尔茨海默病（AD）的主要病理包括淀粉样蛋白和 tau 的联系尚不清楚。
使用基于体素的回归，我们评估了 72 名 MCI 患者空间匹配的 FDG-PET 中淀粉样蛋白和 tau-PET 之间的局部相互作用。对照组包括脑脊液生物标志物特征认知正常（CN，n=70）和 AD 痴呆患者（n=95）。
在 MCI 中，在前额、外侧颞叶和后顶叶区域发现了显著的淀粉样蛋白与 tau-PET 相互作用，其中局部 tau-PET 越高，与低水平局部淀粉样蛋白相应的空间匹配 FDG-PET 越高。与 CN 和 AD 痴呆相比，在具有显著局部淀粉样蛋白与 tau-PET 相互作用的脑区，FDG-PET 更高，且与情景记忆受损相关。
在低淀粉样蛋白存在的情况下，tau-PET 越高与异常增加的葡萄糖代谢相关，伴有情景记忆障碍。
