Tammam Mohamed A, Pereira Florbela, Skellam Elizabeth, Bidula Stefan, Ganesan A, El-Demerdash Amr
Department of Biochemistry, Faculty of Agriculture, Fayoum University, Fayoum 63514, Egypt.
LAQV REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829516 Caparica, Portugal.
Nat Prod Rep. 2025 May 22;42(5):788-841. doi: 10.1039/d4np00076e.
Covering: 2000-2023Cytochalasans are a fascinating class of natural products that possess an intricate chemical structure with a diverse range of biological activities. They are known for their complex chemical architectures and are often isolated from various fungi. These compounds have attracted attention due to their potential pharmacological properties, including antimicrobial, antiviral, and anticancer effects. For decades, researchers have studied these molecules to better understand their mechanisms of action and to explore their potential applications in medicine and other fields. This review article aims to shed light over the period 2000-2023 on the structural diversities of 424 fungal derived cytochalasans, insights into their biosynthetic origins, pharmacokinetics and their promising therapeutic potential in drug discovery and development.
2000年至2023年
细胞松弛素是一类迷人的天然产物，具有复杂的化学结构和多样的生物活性。它们以其复杂的化学结构而闻名，通常从各种真菌中分离得到。这些化合物因其潜在的药理特性而受到关注，包括抗菌、抗病毒和抗癌作用。几十年来，研究人员一直在研究这些分子，以更好地了解其作用机制，并探索它们在医学和其他领域的潜在应用。这篇综述文章旨在阐述2000年至2023年期间424种真菌来源的细胞松弛素的结构多样性、对其生物合成起源、药代动力学以及它们在药物发现和开发中有望的治疗潜力的见解。
