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用于同时测定药物和生物样品中对乙酰氨基酚和氯喹的双层膜修饰玻碳电极

Bilayered Film Modified Glassy Carbon Electrode for the Simultaneous Determination of Paracetamol and Chloroquine in Pharmaceutical and Biological Samples.

作者信息

Gashu Mulu, Aragaw Belete Asefa, Tefera Molla, Abebe Atakilt

机构信息

Department of Chemistry, College of Science, Bahir Dar University, P.O.Box 79, Bahir Dar 1000, Ethiopia.

Department of Chemistry, College of Natural and Computational Sciences, Mekdela Amba University, Mekane Selam 1000, Ethiopia.

出版信息

ACS Omega. 2025 Feb 5;10(6):5601-5615. doi: 10.1021/acsomega.4c08563. eCollection 2025 Feb 18.

DOI:10.1021/acsomega.4c08563
PMID:39989786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11840614/
Abstract

A new, cost-effective selective and highly sensitive electrochemical sensor (poly(cobalt(II) bis(1,10-phenanthroline) and copper(I) bis(2,2-bipyrdine)), poly(Co(Phen)/Cu(Bip))/GCE) was synthesized based on the sequential electropolymerization of diaquabis(1,10-phenanthroline) cobalt(II)iodide dehydrate ([Co(Phen)(HO)]I·2HO) and bis(2,2'-bipyridine)hydroxyl copper(II) iodide ([Cu(Bip)OH]I) at a glassy carbon electrode. The established sensor (poly(Co(Phen)/Cu(Bip))/GCE)) was employed for the simultaneous electrochemical determination of paracetamol (PCM) and chloroquine (CQ). The established sensor was characterized by FTIR, cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The electrochemical performance of unmodified GCE and poly(Co(Phen)/Cu(Bip))/GCE was evaluated for the simultaneous voltammetric determination of PCM and CQ. Using poly(Co(Phen)/Cu(Bip))/GCE and optimized conditions, the simultaneous square wave voltammetric determination of PCM and CQ shows linearity in the concentration range between 0.5 and 200 μM, with sensitivity of 0.389 and 0.462 μA/μM and detection limits (LOD) of (3δ/m) 4.38 × 10 and 7.48 × 10 μM, respectively. Poly(Co(Phen)/Cu(Bip))/GCE showed excellent performance for the simultaneous sensing of PCM and CQ in pharmaceutical, serum, and urine samples, with spiked recoveries exceeding 98.9, 97.9, and 98.2%, respectively, demonstrating low LOD, excellent sensitivity, admirable selectivity, venerable repeatability, and long-lasting stability. Poly(Co(Phen)/Cu(Bip))/GCE's selectivity for the simultaneous determination of PCM and CQ was shown, demonstrating excellent selectivity despite potential interferences like sulfamethoxazole (SMX), salbutamol (SBM), guanine (Gua), and atorvastatin (ATS). These results designate that poly(Co(Phen)/Cu(Bip))/GCE exhibits admirable applicability for the simultaneous electrochemical sensing of PCM and CQ in various real samples.

摘要

基于二水合碘化双（1,10 - 菲啰啉）钴（II）（[Co(Phen)(H₂O)]I·2H₂O）和碘化羟基双（2,2'-联吡啶）铜（II）（[Cu(Bip)OH]I）在玻碳电极上的顺序电聚合，合成了一种新型、具有成本效益、选择性高且灵敏度高的电化学传感器（聚（钴（II）双（1,10 - 菲啰啉）和铜（I）双（2,2 - 联吡啶）），聚（Co(Phen)/Cu(Bip)）/GCE）。所制备的传感器（聚（Co(Phen)/Cu(Bip)）/GCE）用于对乙酰氨基酚（PCM）和氯喹（CQ）的同时电化学测定。通过傅里叶变换红外光谱（FTIR）、循环伏安法（CV）和电化学阻抗谱（EIS）对所制备的传感器进行了表征。评估了未修饰的玻碳电极（GCE）和聚（Co(Phen)/Cu(Bip)）/GCE用于PCM和CQ同时伏安测定的电化学性能。使用聚（Co(Phen)/Cu(Bip)）/GCE并在优化条件下，PCM和CQ的同时方波伏安测定在0.5至200 μM的浓度范围内呈线性，灵敏度分别为0.389和0.462 μA/μM，检测限（3δ/m）分别为4.38×10⁻⁸和7.48×10⁻⁸ μM。聚（Co(Phen)/Cu(Bip)）/GCE在药物、血清和尿液样品中对PCM和CQ的同时传感表现出优异的性能，加标回收率分别超过98.9%、97.9%和98.2%，表明其具有低检测限、优异的灵敏度、良好的选择性、出色的重复性和持久的稳定性。展示了聚（Co(Phen)/Cu(Bip)）/GCE对PCM和CQ同时测定的选择性，尽管存在磺胺甲恶唑（SMX）、沙丁胺醇（SBM）、鸟嘌呤（Gua）和阿托伐他汀（ATS）等潜在干扰，但仍表现出优异的选择性。这些结果表明聚（Co(Phen)/Cu(Bip)）/GCE在各种实际样品中对PCM和CQ的同时电化学传感具有良好的适用性。

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