Yalkowsky S H, Rubino J T
J Pharm Sci. 1985 Apr;74(4):416-21. doi: 10.1002/jps.2600740410.
An equation describing solubilization in aqueous systems by cosolvents was developed by treating a mixed solvent as a linear combination of its components. This equation can successfully explain both the exponential increases and the exponential decreases in aqueous solubility that are frequently observed with the addition of cosolvent. It also provides a means of estimating to what extent a particular drug can be solubilized and how much cosolvent would be required to accomplish a particular degree of solubilization.
通过将混合溶剂视为其各组分的线性组合，得出了一个描述助溶剂在水体系中增溶作用的方程。该方程能够成功解释添加助溶剂时经常观察到的水溶性呈指数增加和指数降低的现象。它还提供了一种方法，用于估计特定药物能够被增溶的程度以及实现特定增溶程度所需的助溶剂量。
