Bhanushali Jay, Ghewade Babaji, Jadhav Ulhas, Reddy Bingu Shiv Kiran, Agarwal Nikhil, Sindhu Arman
Respiratory Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Deemed to be University, Wardha, IND.
Pathology and Laboratory Medicine, Excel Diagnostics, Pune, IND.
Cureus. 2025 Jan 25;17(1):e77971. doi: 10.7759/cureus.77971. eCollection 2025 Jan.
Tuberculosis (TB) remains a significant global health concern, particularly in high-burden countries. Pleural involvement, such as pleural thickening and trapped lung, is a common complication of tuberculous empyema, often leading to respiratory compromise and reduced quality of life. In this case report, a 58-year-old male farmer presented with progressive breathlessness and orthopnea, indicative of pleural pathology. Diagnostic thoracocentesis confirmed an exudative effusion positive for complex using the cartridge-based nucleic acid amplification test (CBNAAT), which is a molecular test that can detect in two hours only. Prompt initiation of anti-TB therapy (anti-Koch's treatment (AKT)) and intercostal drain insertion were performed to manage the tuberculous empyema. Imaging studies revealed pleural thickening and trapped lung, necessitating further intervention. The patient underwent lung decortication, involving extensive removal of fibrous pleural tissue, which resulted in symptomatic improvement. After the procedure, the patient successfully weaned off mechanical ventilation and achieved near-complete resolution over time. This case highlights the effective management of pleural thickening and trapped lung resulting from tuberculous empyema. The timely initiation of AKT, along with interventional procedures like lung decortication, can lead to significant improvement in symptoms and quality of life for patients with TB-related pleural complications. By addressing these complications promptly, healthcare providers can mitigate disability-adjusted life years (DALYs) associated with TB, particularly in regions with a high burden of the disease.
结核病(TB)仍然是一个重大的全球卫生问题,在高负担国家尤为如此。胸膜受累,如胸膜增厚和肺陷闭,是结核性脓胸的常见并发症,常导致呼吸功能受损和生活质量下降。在本病例报告中,一名58岁的男性农民出现进行性呼吸困难和端坐呼吸,提示胸膜病变。诊断性胸腔穿刺术证实为渗出性胸腔积液,使用基于 cartridge 的核酸扩增试验(CBNAAT)检测结核分枝杆菌复合物呈阳性,这是一种仅需两小时就能检测出结核分枝杆菌的分子检测方法。迅速开始抗结核治疗(抗痨治疗(AKT))并插入肋间引流管以治疗结核性脓胸。影像学检查显示胸膜增厚和肺陷闭,需要进一步干预。患者接受了胸膜纤维板剥脱术,广泛切除纤维性胸膜组织,症状得到改善。术后,患者成功脱机,随着时间推移症状几乎完全缓解。本病例突出了对结核性脓胸导致的胸膜增厚和肺陷闭的有效管理。及时开始抗痨治疗,以及像胸膜纤维板剥脱术这样的介入程序,可以显著改善结核病相关胸膜并发症患者的症状和生活质量。通过及时处理这些并发症,医疗服务提供者可以减轻与结核病相关的残疾调整生命年(DALYs),特别是在疾病负担高的地区。