Defective macrophage function in wound repair of P/J mice.

The strength of healing full-thickness incised dermal wounds in P/J mice was less than that of CD-1 mice although the strength of intact skin was similar for each strain. Five days after surgery, P/J mice had wounds with tensile strengths of 65 +/- 18g while CD-1 mice had wounds with strengths of 85 +/- 15g. The wound breaking strength of P/J mice was restored to normal values (86 +/- 18g) by administering glucan. The consequence of defective monocytes in wound repair is discussed in reference to P/J mice.