Wei Yuyang, Chen Yijie, Jia Sihan, Yan Lingyun, Bi Luzheng
Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK.
Department of Mechanical, Aerospace and Civil Engineering, University of Manchester, Manchester M13 9PL, UK.
Biomimetics (Basel). 2025 Feb 18;10(2):119. doi: 10.3390/biomimetics10020119.
This study presents a comprehensive three-dimensional finite element (FE) model inspired by the biomechanics of the human knee, specifically the tibiofemoral joint during the gait cycle. Drawing from natural biological systems, the model integrates bio-inspired elements, including transversely isotropic materials, to replicate the anisotropic properties of ligaments and cartilage, along with anatomically realistic bone and meniscus structures. This dual-material approach ensures a physiologically accurate representation of knee mechanics under varying conditions. The model effectively captures key biomechanical parameters, including a maximum medial tibial cartilage contact pressure of 16.75 MPa at 25% of the stance phase and a maximum femoral cartilage pressure of 10.57 MPa at 75% of the stance phase. Furthermore, its strong correlation with in vivo and in vitro data highlights its potential for clinical applications in orthopedics, such as pre-surgical planning and post-operative assessments. By bridging the gap between biomechanics and bioinspired design, this research contributes significantly to the field of biomimetics and offers a robust simulation tool for enhancing joint protection strategies and optimizing implant designs.
本研究提出了一个全面的三维有限元（FE）模型，该模型受人类膝关节生物力学启发，特别是步态周期中的胫股关节。该模型借鉴自然生物系统，整合了受生物启发的元素，包括横向各向同性材料，以复制韧带和软骨的各向异性特性，以及解剖学上逼真的骨骼和半月板结构。这种双材料方法确保了在不同条件下对膝关节力学的生理准确表征。该模型有效地捕捉了关键生物力学参数，包括在站立阶段25%时内侧胫骨软骨最大接触压力为16.75MPa，在站立阶段75%时股骨软骨最大压力为10.57MPa。此外，它与体内和体外数据的强相关性突出了其在骨科临床应用中的潜力，如术前规划和术后评估。通过弥合生物力学与受生物启发设计之间的差距，本研究对仿生学领域做出了重大贡献，并提供了一个强大的模拟工具，以加强关节保护策略和优化植入物设计。
